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WFRF:(Oh Jennifer M)
 

Sökning: WFRF:(Oh Jennifer M) > Age-related differe...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005347naa a2200685 4500
001oai:DiVA.org:gih-6980
003SwePub
008220222s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:236908893
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-69802 URI
0247 a https://doi.org/10.1016/j.nbas.2022.1000302 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2369088932 URI
040 a (SwePub)gihd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Motovylyak, Aliceu University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
2451 0a Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer’s disease
264 1b Elsevier,c 2022
338 a electronic2 rdacarrier
520 a Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal to be divided into multiple water compartments and derive measures for orientation dispersion index (ODI), neurite density index (NDI) and volume fraction of isotropic diffusion compartment (FISO). This study aimed to investigate which diffusion metric—fractional anisotropy (FA), mean diffusivity (MD), NDI, ODI, or FISO—is most influenced by aging and reflects cognitive function in a population of healthy older adults at risk for Alzheimer’s disease (AD). Age was significantly associated with all but one diffusion parameters and regions of interest. NDI and MD in the cingulate region adjacent to the cingulate cortex showed a significant association with a composite measure of Executive Function and was proven to partially mediate the relationship between aging and Executive Function decline. These results suggest that both DTI and NODDI parameters are sensitive to age-related differences in white matter regions vulnerable to aging, particularly among older adults at risk for AD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Aging
653 a Alzheimer’s disease (AD)
653 a Diffusion tensor imaging (DTI)
653 a Magnetic resonance imaging (MRI)
653 a Neurite orientation dispersion and density imaging (NODDI)
653 a White matter
653 a E-PABS
653 a EPABS
653 a hjärnhälsa
653 a brain health
653 a Medicin/Teknik
653 a Medicine/Technology
7001 a Vogt, Nicholas M.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Adluru, Nageshu University of Wisconsin, Madison, USA4 aut
7001 a Ma, Yueu University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Wang, Ruiu Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, USA,Fysisk aktivitet och hjärnhälsa4 aut0 (Swepub:gih)rui.wang
7001 a Oh, Jennifer M.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Kecskemeti, Steven R.u University of Wisconsin, Madison, USA4 aut
7001 a Alexander, Andrew L.u University of Wisconsin, Madison, USA4 aut
7001 a Dean, Douglas C.u University of Wisconsin, Madison, USA4 aut
7001 a Gallagher, Catherine L.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Sager, Mark A.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Hermann, Bruce P.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Rowley, Howard A.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Johnson, Sterling C.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Asthana, Sanjayu University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Bendlin, Barbara B.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7001 a Okonkwo, Ozioma C.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut
7102 a University of Wisconsin School of Medicine and Public Health, Madison, USAb University of Wisconsin, Madison, USA4 org
7730 t Aging Braind : Elsevierg 2q 2x 2589-9589
8564 u https://doi.org/10.1016/j.nbas.2022.100030y Fulltext
8564 u https://gih.diva-portal.org/smash/get/diva2:1639857/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.nbas.2022.100030
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6980
8564 8u https://doi.org/10.1016/j.nbas.2022.100030
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:236908893

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