WFRF:(Rigaud C.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 11220naa a2201501 4500 | |
| 001 | oai:gup.ub.gu.se/282482 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-75631 | |
| 009 | oai:lup.lub.lu.se:3fdc90f7-a70c-4947-aa85-0c03da727c04 | |
| 009 | oai:prod.swepub.kib.ki.se:141409310 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2824822 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jalz.2019.04.0012 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-756312 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/3fdc90f7-a70c-4947-aa85-0c03da727c042 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1414093102 URI |
| 040 | a (SwePub)gud (SwePub)orud (SwePub)lud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Vermunt, L.u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
| 245 | 1 0 | a Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype |
| 264 | c 2019-06 | |
| 264 | 1 | b Wiley,c 2019 |
| 500 | a Funding Agency:NIA NIH HHS | |
| 520 | a Introduction: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. Methods: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration. Results: The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical setting, APOE epsilon 4 allele carriership, and abnormal cerebrospinal fluid tau were associated with a shorter duration, and these effects depended on disease stage. Discussion: Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Alzheimer's disease | |
| 653 | a Disease duration | |
| 653 | a Preclinical | |
| 653 | a Prodromal | |
| 653 | a Dementia | |
| 653 | a APOE | |
| 653 | a Clinical setting | |
| 653 | a Progression | |
| 653 | a Multistate model | |
| 653 | a mild cognitive impairment | |
| 653 | a beta-amyloid 1-42 | |
| 653 | a association workgroups | |
| 653 | a diagnostic guidelines | |
| 653 | a national institute | |
| 653 | a risk-factors | |
| 653 | a decline | |
| 653 | a prevalence | |
| 653 | a neurodegeneration | |
| 653 | a recommendations | |
| 653 | a Neurosciences & Neurology | |
| 653 | a khann g | |
| 653 | a 1984 | |
| 653 | a neurology | |
| 653 | a v34 | |
| 653 | a p939 | |
| 653 | a APOE | |
| 700 | 1 | a Sikkes, S. A. M.u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA4 aut |
| 700 | 1 | a van den Hout, A.u Department of Statistical Science, University College London, London, UK4 aut |
| 700 | 1 | a Handels, R.u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut |
| 700 | 1 | a Bos, I.u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut |
| 700 | 1 | a van der Flier, W. M.u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
| 700 | 1 | a Kern, Silkeu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xkersi |
| 700 | 1 | a Ousset, P. J.u CHU Toulouse, Gérontopôle and INSERM UMR 1027, Toulouse, France4 aut |
| 700 | 1 | a Maruff, P.u Cogstate Ltd, Florey Institute, University of Melbourne, Melbourne, Australia4 aut |
| 700 | 1 | a Skoog, Ingmar,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xskooi |
| 700 | 1 | a Verhey, F. R. J.u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut |
| 700 | 1 | a Freund-Levi, Yvonne,d 1956-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Caring Sciences and Society (NVS), Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, UK4 aut0 (Swepub:oru)yfi |
| 700 | 1 | a Tsolaki, M.4 aut |
| 700 | 1 | a Wallin, Åsau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-was |
| 700 | 1 | a Rikkert, M. O.u Department of Geriatric Medicine, Radboudumc Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands4 aut |
| 700 | 1 | a Soininen, H.u Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland4 aut |
| 700 | 1 | a Spiru, L.u "Carol Davila" University of Medicine and Pharmacy, Geriatrics-Gerontology and Old Age Psychiatry Clinical Department -"Elias" University Clinical Hospital, Bucarest, Romenia; "Ana Aslan" International Academy of Aging - The Memory Clinic and Longevity Medicine, Bucarest, Romenia4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Scheltens, P.u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
| 700 | 1 | a Muniz-Terrera, G.u Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK4 aut |
| 700 | 1 | a Visser, P. J.u Karolinska Institutet4 aut |
| 700 | 1 | a Vellas, B.4 aut |
| 700 | 1 | a Reynish, E.4 aut |
| 700 | 1 | a Ousset, P. J.4 aut |
| 700 | 1 | a Andrieu, S.4 aut |
| 700 | 1 | a Burns, A.4 aut |
| 700 | 1 | a Pasquier, F.4 aut |
| 700 | 1 | a Frisoni, G.4 aut |
| 700 | 1 | a Salmon, E.4 aut |
| 700 | 1 | a Michel, J. P.4 aut |
| 700 | 1 | a Zekry, D. S.4 aut |
| 700 | 1 | a Boada, M.4 aut |
| 700 | 1 | a Dartigues, J. F.4 aut |
| 700 | 1 | a Olde-Rikkert, M. G. M.4 aut |
| 700 | 1 | a Rigaud, A. S.4 aut |
| 700 | 1 | a Winblad, B.u Karolinska Institutet4 aut |
| 700 | 1 | a Malick, A.4 aut |
| 700 | 1 | a Sinclair, A.4 aut |
| 700 | 1 | a Frolich, L.4 aut |
| 700 | 1 | a Scheltens, P.4 aut |
| 700 | 1 | a Ribera, C.4 aut |
| 700 | 1 | a Touchon, J.4 aut |
| 700 | 1 | a Robert, P.4 aut |
| 700 | 1 | a Salva, A.4 aut |
| 700 | 1 | a Waldemar, G.4 aut |
| 700 | 1 | a Bullock, R.4 aut |
| 700 | 1 | a Tsolaki, M.4 aut |
| 700 | 1 | a Rodriguez, G.4 aut |
| 700 | 1 | a Spiru, L.4 aut |
| 700 | 1 | a Jones, R. W.4 aut |
| 700 | 1 | a Stiens, G.4 aut |
| 700 | 1 | a Stoppe, G.4 aut |
| 700 | 1 | a Jonhagen, M. E.u Karolinska Institutet4 aut |
| 700 | 1 | a Cherubini, A.4 aut |
| 700 | 1 | a Lage, P. M.4 aut |
| 700 | 1 | a Gomezisla, T.4 aut |
| 700 | 1 | a Camus, V.4 aut |
| 700 | 1 | a Aguera-Morales, E.4 aut |
| 700 | 1 | a Lopez, F.4 aut |
| 700 | 1 | a Savy, S.4 aut |
| 700 | 1 | a Cantet, C.4 aut |
| 700 | 1 | a Coley, N.4 aut |
| 710 | 2 | a Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlandsb Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA4 org |
| 773 | 0 | t Alzheimers & Dementiad : Wileyg 15:7, s. 888-898q 15:7<888-898x 1552-5260x 1552-5279 |
| 856 | 4 | u https://cris.maastrichtuniversity.nl/ws/files/71139666/Handels_2019_Duration_of_preclinical_prodromal_and_dementia_stages.pdf |
| 856 | 4 | u http://dx.doi.org/10.1016/j.jalz.2019.04.001y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/282482 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jalz.2019.04.001 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75631 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3fdc90f7-a70c-4947-aa85-0c03da727c04 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141409310 |
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