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Replication and cro...
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Slieker, Roderick CAmsterdam Public Health
(författare)
Replication and cross-validation of type 2 diabetes subtypes based on clinical variables : an IMI-RHAPSODY study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-06-10
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Springer Science and Business Media LLC,2021
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8 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:5965a29d-09ce-4ce7-b47f-9072aa5d2e50
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https://lup.lub.lu.se/record/5965a29d-09ce-4ce7-b47f-9072aa5d2e50URI
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https://doi.org/10.1007/s00125-021-05490-8DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Aims/hypothesis: Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study we replicate and cross-validate these type 2 diabetes clusters in three large cohorts using variables readily measured in the clinic. Methods: In three independent cohorts, in total 15,940 individuals were clustered based on age, BMI, HbA1c, random or fasting C-peptide, and HDL-cholesterol. Clusters were cross-validated against the original clusters based on HOMA measures. In addition, between cohorts, clusters were cross-validated by re-assigning people based on each cohort’s cluster centres. Finally, we compared the time to insulin requirement for each cluster. Results: Five distinct type 2 diabetes clusters were identified and mapped back to the original four All New Diabetics in Scania (ANDIS) clusters. Using C-peptide and HDL-cholesterol instead of HOMA2-B and HOMA2-IR, three of the clusters mapped with high sensitivity (80.6–90.7%) to the previously identified severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD) and mild obesity-related diabetes (MOD) clusters. The previously described ANDIS mild age-related diabetes (MARD) cluster could be mapped to the two milder groups in our study: one characterised by high HDL-cholesterol (mild diabetes with high HDL-cholesterol [MDH] cluster), and the other not having any extreme characteristic (mild diabetes [MD]). When these two milder groups were combined, they mapped well to the previously labelled MARD cluster (sensitivity 79.1%). In the cross-validation between cohorts, particularly the SIDD and MDH clusters cross-validated well, with sensitivities ranging from 73.3% to 97.1%. SIRD and MD showed a lower sensitivity, ranging from 36.1% to 92.3%, where individuals shifted from SIRD to MD and vice versa. People belonging to the SIDD cluster showed the fastest progression towards insulin requirement, while the MDH cluster showed the slowest progression. Conclusions/interpretation: Clusters based on C-peptide instead of HOMA2 measures resemble those based on HOMA2 measures, especially for SIDD, SIRD and MOD. By adding HDL-cholesterol, the MARD cluster based upon HOMA2 measures resulted in the current clustering into two clusters, with one cluster having high HDL levels. Cross-validation between cohorts showed generally a good resemblance between cohorts. Together, our results show that the clustering based on clinical variables readily measured in the clinic (age, HbA1c, HDL-cholesterol, BMI and C-peptide) results in informative clusters that are representative of the original ANDIS clusters and stable across cohorts. Adding HDL-cholesterol to the clustering resulted in the identification of a cluster with very slow glycaemic deterioration. Graphical abstract: [Figure not available: see fulltext.]
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Donnelly, Louise AUniversity of Dundee
(författare)
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Fitipaldi, HugoLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Istituto Nazionale dei Tumori(Swepub:lu)hu3745fi
(författare)
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Bouland, Gerard ALeiden University Medical Centre
(författare)
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Giordano, Giuseppe NLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Istituto Nazionale dei Tumori(Swepub:lu)med-geg
(författare)
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Åkerlund, MikaelLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Diabetes - öpatofysiologi,Diabetiska komplikationer,Translational Muscle Research,Lund University Research Groups,Diabetes - Islet Patophysiology,Diabetic Complications(Swepub:lu)medk-mak
(författare)
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Gerl, Mathias JLipotype GmbH
(författare)
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Ahlqvist, EmmaLund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Patologi, Malmö,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Pathology, Malmö,Istituto Nazionale dei Tumori(Swepub:lu)infl-eah
(författare)
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Ali, AshfaqSteno Diabetes Center Copenhagen,Gentofte Hospital(Swepub:lu)cob-aaf
(författare)
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Dragan, IulianSwiss Institute for Bioinformatics (SIB)
(författare)
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Festa, AndreasEli Lilly Regional Operations G.m.b.H.
(författare)
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Hansen, Michael KAstraZeneca, Sweden,Janssen Research & Development, Mexico
(författare)
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Mansour Aly, DinaLund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Patologi, Malmö,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Pathology, Malmö,Istituto Nazionale dei Tumori(Swepub:lu)di3053ma
(författare)
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Kim, MinSteno Diabetes Center Copenhagen
(författare)
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Kuznetsov, DmitrySwiss Institute for Bioinformatics (SIB)
(författare)
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Mehl, FlorenceSwiss Institute for Bioinformatics (SIB)
(författare)
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Klose, ChristianLipotype GmbH
(författare)
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Simons, KaiLipotype GmbH
(författare)
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Pavo, ImreEli Lilly Regional Operations G.m.b.H.
(författare)
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Pullen, Timothy JKing's College London
(författare)
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Suvitaival, TommiSteno Diabetes Center Copenhagen
(författare)
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Wretlind, AsgerSteno Diabetes Center Copenhagen
(författare)
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Rossing, PeterSteno Diabetes Center Copenhagen
(författare)
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Lyssenko, ValeriyaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Copenhagen University Hospital,University of Bergen(Swepub:lu)endo-vly
(författare)
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Legido-Quigley, CristinaSteno Diabetes Center Copenhagen
(författare)
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki Haartman Institute(Swepub:lu)endo-lgr
(författare)
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Thorens, BernardUniversity of Lausanne
(författare)
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Franks, Paul WHarvard T.H. Chan School of Public Health(Swepub:lu)med-plf
(författare)
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Ibberson, MarkSwiss Institute for Bioinformatics (SIB)
(författare)
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Rutter, Guy AImperial College London
(författare)
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Beulens, Joline W JAmsterdam Public Health
(författare)
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't Hart, Leen MAmsterdam Public Health
(författare)
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Pearson, Ewan RUniversity of Dundee,Cumming School of Medicine(Swepub:lu)ew1481pe
(författare)
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Amsterdam Public HealthUniversity of Dundee
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer Science and Business Media LLC64:9, s. 1982-19890012-186X1432-0428
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Slieker, Roderic ...
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Donnelly, Louise ...
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Fitipaldi, Hugo
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Bouland, Gerard ...
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Giordano, Giusep ...
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Åkerlund, Mikael
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visa fler...
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Gerl, Mathias J
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Ahlqvist, Emma
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Ali, Ashfaq
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Dragan, Iulian
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Festa, Andreas
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Hansen, Michael ...
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Mansour Aly, Din ...
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Kim, Min
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Kuznetsov, Dmitr ...
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Mehl, Florence
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Klose, Christian
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Simons, Kai
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Pavo, Imre
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Pullen, Timothy ...
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Suvitaival, Tomm ...
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Wretlind, Asger
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Rossing, Peter
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Lyssenko, Valeri ...
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Legido-Quigley, ...
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Groop, Leif
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Thorens, Bernard
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Franks, Paul W
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Ibberson, Mark
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Rutter, Guy A
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Beulens, Joline ...
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't Hart, Leen M
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Pearson, Ewan R
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