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Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome : Jejunal Barrier Alterations Underlying Clinical Manifestations

Pardo-Camacho, Cristina (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
Ganda Mall, John-Peter, 1988- (författare)
Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Vall Hebron Inst Recerca, Spain
Martínez, Cristina (författare)
Vascular and Renal Translational Research Group, Lleida Institute for Biomedical Research Dr. Pifarré. Foundation (IRBLleida), Lleida, Spain,Vasc & Renal Translat Res Grp, Spain
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Pigrau, Marc (författare)
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Spain
Expósito, Elba (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
Albert-Bayo, Mercé (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
Melón-Ardanaz, Elisa (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
Nieto, Adoración (författare)
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Vall Hebron Hosp Univ, Spain
Rodiño-Janeiro, Bruno (författare)
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
Fortea, Marina (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
Guagnozzi, Danila (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Vall Hebron Inst Recerca, Spain; Vall Hebron Hosp Univ, Spain
Rodriguez-Urrutia, Amanda (författare)
Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Mental Health, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain,Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
de Torres, Inés (författare)
Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Pathology, Hospital Universitari Vall d'Hebrón, Barcelona, Spain,Univ Autonoma Barcelona, Spain; Hosp Univ Vall Hebron, Spain
Santos-Briones, Ignacio (författare)
Facultat Ciències de la Salut, Universitat Ramon LLull-Blanquerna, Barcelona, Spain,Univ Ramon LLull Blanquerna, Spain
Azpiroz, Fernando (författare)
Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
Lobo, Beatriz (författare)
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain
Alonso-Cotoner, Carmen (författare)
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
Santos, Javier (författare)
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
González-Castro, Ana M. (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
Vicario, Maria (författare)
Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastrointestinal Health, Nestlé Institute of Health Sciences, Société des Produits Nestlé S.A., Nestlé Research, Vers-chez-les-Blanc, Lausanne, Switzerland
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 (creator_code:org_t)
2022-06-28
2022
Engelska.
Ingår i: Cells. - Basel : MDPI. - 2073-4409. ; 11:13
Relaterad länk:
https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Irritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterised by abdominal pain and changes in bowel habits. In the diarrhoea subtype (IBS-D), altered epithelial barrier and mucosal immune activation are associated with clinical manifestations. We aimed to further evaluate plasma cells and epithelial integrity to gain understanding of IBS-D pathophysiology. One mucosal jejunal biopsy and one stool sample were obtained from healthy controls and IBS-D patients. Gastrointestinal symptoms, stress, and depression scores were recorded. In the jejunal mucosa, RNAseq and gene set enrichment analyses were performed. A morphometric analysis by electron microscopy quantified plasma cell activation and proximity to enteric nerves and glycocalyx thickness. Immunoglobulins concentration was assessed in the stool. IBS-D patients showed differential expression of humoral pathways compared to controls. Activation and proximity of plasma cells to nerves and IgG concentration were also higher in IBS-D. Glycocalyx thickness was lower in IBS-D compared to controls, and this reduction correlated with plasma cell activation, proximity to nerves, and clinical symptoms. These results support humoral activity and loss of epithelial integrity as important contributors to gut dysfunction and clinical manifestations in IBS-D. Additional studies are needed to identify the triggers of these alterations to better define IBS-D pathophysiology. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Nyckelord

IBS-D
intestinal barrier dysfunction
intestinal glycocalyx
intestinal plasma cells
mucosal nerve fibres
mucosal ultrastructure

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