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Gemcitabine versus ...
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Sederholm, ChristerÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Lungmedicin,Lungmedicinska kliniken US
(författare)
Gemcitabine versus gemcitabine/carboplatin in advanced non-small cell lung cancer : Preliminary findings in a phase III trial of the Swedish Lung Cancer Study Group
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
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Elsevier BV,2002
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-27127
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-27127URI
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https://doi.org/10.1053/sonc.2002.34276DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Gemcitabine is an active agent in non-small cell lung cancer, with single-agent treatment producing response rates of approximately 20% and median survivals of approximately 7 to 9 months. In a pilot trial in advanced non-small cell lung cancer, the gemcitabine/ carboplatin combination produced a response rate of 43% and median survival of 12 months with good tolerability. Preliminary results of a phase III trial comparing gemcitabine alone with gemcitabine/carboplatin in 332 patients with stage IIIB or IV non-small cell lung cancer are now available. Patients were randomized to receive gemcitabine 1,250 mg/m2 on days 1 and 8 every 21 days or the same gemcitabine regimen plus carboplatin at an area under the concentration-time curve of 5 mg/mL/min on day 1 for a maximum of six cycles. Hematologic toxicity was more common in the combination arm, grade 4 thrombocytopenia occurred in 23.5% v 5.3% of patients, but infrequently resulted in clinical complications. Nonhematologic toxicity was moderate and similar in frequency in the combination and gemcitabine arms (25% and 28%, respectively). Among 275 patients, overall response rates were 30% (2% complete response and 28% partial response) in the combination arm and 12% (all partial responses) in the gemcitabine arm. Median time to disease progression was 6 months in the combination arm and 4 months in the gemcitabine arm. Median survival in the study population was 9 months, a promising finding given the high proportion of elderly patients in the study (37% = 70 years of age). Full mature results of the trial, including comparative survival results and data on quality of life, are awaited. Copyright 2002, Elsevier Science (USA). All rights reserved.
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Linköpings universitetHälsouniversitetet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Seminars in Oncology: Elsevier BV29:3 SUPPL. 9, s. 50-540093-77541532-8708
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