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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006046naa a2200745 4500
001oai:lup.lub.lu.se:0663142b-95f8-4c9e-a215-912a885e6805
003SwePub
008170419s1989 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/0663142b-95f8-4c9e-a215-912a885e68052 URI
0247 a https://doi.org/10.1001/archneur.1989.005204200330212 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lindvall, Ou Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-oli
2451 0a Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up
264 1b American Medical Association (AMA),c 1989
520 a By using stereotaxic surgical techniques, ventral mesencephalic tissues from aborted human fetuses of 8 to 10 weeks' gestational age were implanted unilaterally into the striata in two patients with advanced Parkinson's disease. The patients were treated with a cyclosporine, azathioprine, and steroid regimen to minimize the risk for graft rejection. They were examined for 6 months preoperatively and 6 months postoperatively and continued to receive the same doses of antiparkinsonian medication. There were no significant postoperative complications. No major therapeutic effect from the operation was observed. However, in the clinical tests, both patients showed small but significant increases of movement speed for repeated pronation-supination, fist clenching, and foot lifting. The rate of walking also increased in the one patient tested. For both patients, there was an initial worsening postoperatively, followed by improvement vs preoperative performance at 1 to 3 months. Both patients also showed significant improvement in the magnitude of response to a single dose of levodopa (L-dopa), but there was no increase in the duration of drug action. The motor readiness potential increased in both patients postoperatively, primarily over the operated hemisphere. Neurophysiological measurements also showed a more rapid performance of simple and complex arm and hand movements on the side contralateral to transplantation in one patient at 5 months postoperatively. Positron emission tomography demonstrated no increased uptake of 6-L-(18F)-fluorodopa in the transplanted striatum at 5 and 6 months. Taken together, these results suggest that the fetal nigral implants may have provided a modest improvement in motor function, consistent with the presence of small surviving grafts. Although our results support further scientific experimentation with transplantation in Parkinson's disease, widespread clinical trials with this procedure are probably not warranted at this time.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Contingent Negative Variation
653 a Corpus Striatum
653 a Dopamine
653 a Female
653 a Fetus
653 a Follow-Up Studies
653 a Humans
653 a Levodopa
653 a Methods
653 a Middle Aged
653 a Movement
653 a Nerve Tissue
653 a Neurologic Examination
653 a Neurons
653 a Neuropsychological Tests
653 a Parkinson Disease
653 a Self Concept
653 a Tomography, Emission-Computed
653 a Journal Article
653 a Research Support, Non-U.S. Gov't
7001 a Rehncrona, Su Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)nkir-sre
7001 a Brundin, Pu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-pbr
7001 a Gustavii, Bu Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-bjg
7001 a Astedt, B4 aut
7001 a Widner, Hu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Regeneration in Movement Disorders,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)mphy-hwi
7001 a Lindholm, Torun4 aut
7001 a Björklund, Au Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-abj
7001 a Leenders, K L4 aut
7001 a Rothwell, J C4 aut
7001 a Frackowiak, R S4 aut
7001 a Marsden, C D4 aut
7001 a Johnels, B4 aut
7001 a Steg, Pierre G4 aut
7001 a Freedman, R4 aut
7001 a Hoffer, B J4 aut
7001 a Seiger, Ake4 aut
7001 a Bygdeman, M4 aut
7001 a Strömberg, I4 aut
7001 a Olson, L.4 aut
7102 a Neurologi, Lundb Sektion IV4 org
7730 t Archives of Neurologyd : American Medical Association (AMA)g 46:6, s. 31-615q 46:6<31-615x 0003-9942
8564 u http://dx.doi.org/10.1001/archneur.1989.00520420033021y FULLTEXT
8564 8u https://lup.lub.lu.se/record/0663142b-95f8-4c9e-a215-912a885e6805
8564 8u https://doi.org/10.1001/archneur.1989.00520420033021

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