A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

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Fältnamn	Indikatorer	Metadata
000		06891naa a2201621 4500
001		oai:DiVA.org:umu-42266
003		SwePub
008		110406s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-422662 URI
024	7	a https://doi.org/10.1038/ng.6872 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Rothman, Nathaniel4 aut
245	1 0	a A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
264		c 2010-10-24
264	1	b Springer Science and Business Media LLC,c 2010
338		a print2 rdacarrier
520		a We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a confers susceptibility; udp-glucuronosyltransferases; recombination hotspots; telomerase mutations; pulmonary-fibrosis; sequence variant; common variants; chromosome 8q24; down-regulation; cell-carcinoma
700	1	a Garcia-Closas, Montserrat4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a Malats, Nuria4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Figueroa, Jonine D4 aut
700	1	a Real, Francisco X4 aut
700	1	a Van Den Berg, David4 aut
700	1	a Matullo, Giuseppe4 aut
700	1	a Baris, Dalsu4 aut
700	1	a Thun, Michael4 aut
700	1	a Kiemeney, Lambertus A4 aut
700	1	a Vineis, Paolo4 aut
700	1	a De Vivo, Immaculata4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Purdue, Mark P4 aut
700	1	a Rafnar, Thorunn4 aut
700	1	a Hildebrandt, Michelle A T4 aut
700	1	a Kiltie, Anne E4 aut
700	1	a Cussenot, Olivier4 aut
700	1	a Golka, Klaus4 aut
700	1	a Kumar, Rajiv4 aut
700	1	a Taylor, Jack A4 aut
700	1	a Mayordomo, Jose I4 aut
700	1	a Jacobs, Kevin B4 aut
700	1	a Kogevinas, Manolis4 aut
700	1	a Hutchinson, Amy4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Fu, Yi-Ping4 aut
700	1	a Prokunina-Olsson, Ludmila4 aut
700	1	a Burdett, Laurie4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Wheeler, William4 aut
700	1	a Tardón, Adonina4 aut
700	1	a Serra, Consol4 aut
700	1	a Carrato, Alfredo4 aut
700	1	a García-Closas, Reina4 aut
700	1	a Lloreta, Josep4 aut
700	1	a Johnson, Alison4 aut
700	1	a Schwenn, Molly4 aut
700	1	a Karagas, Margaret R4 aut
700	1	a Schned, Alan4 aut
700	1	a Andriole, Gerald4 aut
700	1	a Grubb, Robert4 aut
700	1	a Black, Amanda4 aut
700	1	a Jacobs, Eric J4 aut
700	1	a Diver, W Ryan4 aut
700	1	a Gapstur, Susan M4 aut
700	1	a Weinstein, Stephanie J4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Cortessis, Victoria K4 aut
700	1	a Gago-Dominguez, Manuela4 aut
700	1	a Pike, Malcolm C4 aut
700	1	a Stern, Mariana C4 aut
700	1	a Yuan, Jian-Min4 aut
700	1	a Hunter, David J4 aut
700	1	a McGrath, Monica4 aut
700	1	a Dinney, Colin P4 aut
700	1	a Czerniak, Bogdan4 aut
700	1	a Chen, Meng4 aut
700	1	a Yang, Hushan4 aut
700	1	a Vermeulen, Sita H4 aut
700	1	a Aben, Katja K4 aut
700	1	a Witjes, J Alfred4 aut
700	1	a Makkinje, Remco R4 aut
700	1	a Sulem, Patrick4 aut
700	1	a Besenbacher, Soren4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Riboli, Elio4 aut
700	1	a Brennan, Paul4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Navarro, Carmen4 aut
700	1	a Allen, Naomi E4 aut
700	1	a Bueno-de-Mesquita, H Bas4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Caporaso, Neil4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Canzian, Federico4 aut
700	1	a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001
700	1	a Tjonneland, Anne4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Bishop, David T4 aut
700	1	a Teo, Mark T W4 aut
700	1	a Knowles, Margaret A4 aut
700	1	a Guarrera, Simonetta4 aut
700	1	a Polidoro, Silvia4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Allione, Alessandra4 aut
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Selinski, Silvia4 aut
700	1	a Hengstler, Jan G4 aut
700	1	a Dietrich, Holger4 aut
700	1	a Fletcher, Tony4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Gurzau, Eugen4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Bolick, Sophia C E4 aut
700	1	a Godfrey, Ashley4 aut
700	1	a Xu, Zongli4 aut
700	1	a Sanz-Velez, José I4 aut
700	1	a D García-Prats, María4 aut
700	1	a Sanchez, Manuel4 aut
700	1	a Valdivia, Gabriel4 aut
700	1	a Porru, Stefano4 aut
700	1	a Benhamou, Simone4 aut
700	1	a Hoover, Robert N4 aut
700	1	a Fraumeni, Joseph F4 aut
700	1	a Silverman, Debra T4 aut
700	1	a Chanock, Stephen J4 aut
710	2	a Umeå universitetb Urologi och andrologi4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 42:11, s. 978-984q 42:11<978-984x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc3049891?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42266
856	4 8	u https://doi.org/10.1038/ng.687

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Av författaren/redakt...: Rothman, Nathani ...; Garcia-Closas, M ...; Chatterjee, Nila ...; Malats, Nuria; Wu, Xifeng; Figueroa, Jonine ...; visa fler...; Real, Francisco ...; Van Den Berg, Da ...; Matullo, Giusepp ...; Baris, Dalsu; Thun, Michael; Kiemeney, Lamber ...; Vineis, Paolo; De Vivo, Immacul ...; Albanes, Demetri ...; Purdue, Mark P; Rafnar, Thorunn; Hildebrandt, Mic ...; Kiltie, Anne E; Cussenot, Olivie ...; Golka, Klaus; Kumar, Rajiv; Taylor, Jack A; Mayordomo, Jose ...; Jacobs, Kevin B; Kogevinas, Manol ...; Hutchinson, Amy; Wang, Zhaoming; Fu, Yi-Ping; Prokunina-Olsson ...; Burdett, Laurie; Yeager, Meredith; Wheeler, William; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; García-Closas, R ...; Lloreta, Josep; Johnson, Alison; Schwenn, Molly; Karagas, Margare ...; Schned, Alan; Andriole, Gerald; Grubb, Robert; Black, Amanda; Jacobs, Eric J; Diver, W Ryan; Gapstur, Susan M; Weinstein, Steph ...; Virtamo, Jarmo; Cortessis, Victo ...; Gago-Dominguez, ...; Pike, Malcolm C; Stern, Mariana C; Yuan, Jian-Min; Hunter, David J; McGrath, Monica; Dinney, Colin P; Czerniak, Bogdan; Chen, Meng; Yang, Hushan; Vermeulen, Sita ...; Aben, Katja K; Witjes, J Alfred; Makkinje, Remco ...; Sulem, Patrick; Besenbacher, Sor ...; Stefansson, Kari; Riboli, Elio; Brennan, Paul; Panico, Salvator ...; Navarro, Carmen; Allen, Naomi E; Bueno-de-Mesquit ...; Trichopoulos, Di ...; Caporaso, Neil; Landi, Maria Ter ...; Canzian, Federic ...; Ljungberg, Börje; Tjonneland, Anne; Clavel-Chapelon, ...; Bishop, David T; Teo, Mark T W; Knowles, Margare ...; Guarrera, Simone ...; Polidoro, Silvia; Ricceri, Fulvio; Sacerdote, Carlo ...; Allione, Alessan ...; Cancel-Tassin, G ...; Selinski, Silvia; Hengstler, Jan G; Dietrich, Holger; Fletcher, Tony; Rudnai, Peter; Gurzau, Eugen; Koppova, Kvetosl ...; Bolick, Sophia C ...; Godfrey, Ashley; Xu, Zongli; Sanz-Velez, José ...; D García-Prats, ...; Sanchez, Manuel; Valdivia, Gabrie ...; Porru, Stefano; Benhamou, Simone; Hoover, Robert N; Fraumeni, Joseph ...; Silverman, Debra ...; Chanock, Stephen ...; visa färre...

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