Neurotensin-induced modulation of spinal neurons and fictive locomotion in the lamprey

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Fältnamn	Indikatorer	Metadata
000		02188naa a2200253 4500
001		oai:prod.swepub.kib.ki.se:1930356
003		SwePub
008		240701s1995 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:19303562 URI
024	7	a https://doi.org/10.1152/jn.1995.73.3.13082 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a BARTHE, JY4 aut
245	1 0	a Neurotensin-induced modulation of spinal neurons and fictive locomotion in the lamprey
264	1	b American Physiological Society,c 1995
520		a 1. Neurotensin containing interneurons are present in the spinal cord of both mammalian and nonmammalian vertebrates, but as yet little is known about their functional role. In this study we examine the effect of neurotensin on spinal cells and on the central pattern generator for locomotion in the lamprey spinal cord. 2. Bath application of neurotensin (10(-8) to 10(-6) M) slowed down the fictive locomotor activity induced by the glutamate agonist N-methyl-D-aspartate in the isolated spinal cord. The duration of the bursts of activity in the ventral roots increased in proportion to the increase of the locomotor cycle duration. 3. Intracellular recordings from grey matter neurons and intraspinal stretch receptors neurons showed that neurotensin induced a depolarization [4.4 +/- 0.5 (SE) mV, n = 19]. This depolarization could still be obtained after a blockade of voltage-sensitive sodium channels with tetrodotoxin (1.5 +/- 0.5 mV; n = 6), and after removal of calcium (2.8 +/- 0.4 mV; n = 5). Moreover no consistent change occurred in the fast and slow phase of the afterhyperpolarization (AHP) both of which are carried by potassium currents.
700	1	a GRILLNER, Su Karolinska Institutet4 aut
710	2	a Karolinska Institutet4 org
773	0	t Journal of neurophysiologyd : American Physiological Societyg 73:3, s. 1308-1312q 73:3<1308-1312x 0022-3077x 1522-1598
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:1930356
856	4 8	u https://doi.org/10.1152/jn.1995.73.3.1308

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Av författaren/redakt...: BARTHE, JY; GRILLNER, S

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Av lärosätet: Karolinska Institutet

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