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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03003naa a2200397 4500 | |
| 001 | oai:research.chalmers.se:790e4821-5a0f-4bae-9a92-7587e694615d | |
| 003 | SwePub | |
| 008 | 171008s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://research.chalmers.se/publication/2164022 URI |
| 024 | 7 | a https://doi.org/10.1007/s11051-014-2368-42 DOI |
| 040 | a (SwePub)cth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Coelho, S. C.u Universidade do Porto,University of Porto4 aut |
| 245 | 1 0 | a Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers |
| 264 | c 2014-04-01 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2014 |
| 520 | a Organic-inorganic hybrid nanoparticles are potential effective systems for drug delivery in cancer therapy and diagnosis. Chitosan-gum arabic with entrapped gold nanoparticles were developed as a carrier for an anticancer drug bortezomib. The nanosystem was designed to enhance the proteasome inhibitor activity in pancreatic cell lines, S2-013 and hTERT-HPNE. The hydrodynamic diameter of chitosan-gum arabic-gold nanoparticles loaded with bortezomib is around 330 nm. Laser scanning confocal microscopy images show the uptake of the gold nanoparticle/bortezomib encapsulated in chitosan-gum arabic matrix and the fast internalization of these nano combinations into pancreatic cells. Cytotoxic assays assessed that positively charged nanosystems reduce the cell growth and cell proliferation of S2-013s, but the same effect was not observed in cytotoxic response in hTERT-HPNE cells. The outcomes of this study demonstrate the capacity of chitosan-gum arabic nanocarriers to deliver gold nanoparticles/anticancer drug and to increase the permeation and retention effect in S2-013 cells and minimize drug side effects in HPNE cells. © 2014 Springer Science+Business Media. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng |
| 653 | a Cellular uptake | |
| 653 | a Healthy effects | |
| 653 | a Cancer cells | |
| 653 | a Polysaccharides | |
| 653 | a Gold nanoparticles | |
| 700 | 1 | a Rocha, Sandra,d 1975u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)rochas |
| 700 | 1 | a Sampaio, P.u Instituto de Biologia Molecular e Celular4 aut |
| 700 | 1 | a Pereira, M. C.u Universidade do Porto,University of Porto4 aut |
| 700 | 1 | a Coelho, M. A. N.u Universidade do Porto,University of Porto4 aut |
| 710 | 2 | a Universidade do Portob Chalmers tekniska högskola4 org |
| 773 | 0 | t Journal of Nanoparticle Researchd : Springer Science and Business Media LLCg 16:4q 16:4x 1388-0764x 1572-896X |
| 856 | 4 | u https://repositorio-aberto.up.pt/bitstream/10216/103252/2/106046.1.pdf |
| 856 | 4 8 | u https://research.chalmers.se/publication/216402 |
| 856 | 4 8 | u https://doi.org/10.1007/s11051-014-2368-4 |
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