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  • Björnsson, Marcus A.Uppsala universitet,Institutionen för farmaceutisk biovetenskap (author)

A two-compartment effect site model describes the bispectral index after different rates of propofol infusion

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-04-23
  • Springer Science and Business Media LLC,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-136145
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136145URI
  • https://doi.org/10.1007/s10928-010-9157-1DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:120898840URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Different estimates of the rate constant for the effect site distribution (k(e0)) of propofol, depending on the rate and duration of administration, have been reported. This analysis aimed at finding a more general pharmacodynamic model that could be used when the rate of administration is changed during the treatment. In a cross-over study, 21 healthy volunteers were randomised to receive a 1 min infusion of 2 mg/kg of propofol at one occasion, and a 1 min infusion of 2 mg/kg of propofol immediately followed by a 29 min infusion of 12 mg kg(-1) h(-1) of propofol at another occasion. Arterial plasma concentrations of propofol were collected up to 4 h after dosing, and BIS was collected before start of infusion and until the subjects were fully awake. The population pharmacokinetic-pharmacodynamic analysis was performed using NONMEM VI. A four-compartment PK model with time-dependent elimination and distribution described the arterial propofol concentrations, and was used as input to the pharmacodynamic model. A standard effect compartment model could not accurately describe the delay in the effects of propofol for both regimens, whereas a two-compartment effect site model significantly improved the predictions. The two-compartment effect site model included a central and a peripheral effect site compartment, possibly representing a distribution within the brain, where the decrease in BIS was linked to the central effect site compartment concentrations through a sigmoidal E-max model.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Norberg, AkeKarolinska Institutet (author)
  • Kalman, SigridurKarolinska Institutet (author)
  • Karlsson, Mats O.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakometri(Swepub:uu)matskarl (author)
  • Simonsson, Ulrika S. H.Uppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)usv12211 (author)
  • Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

Related titles

  • In:Journal of Pharmacokinetics and Pharmacodynamics: Springer Science and Business Media LLC37:3, s. 243-2551567-567X1573-8744

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Björnsson, Marcu ...
Norberg, Ake
Kalman, Sigridur
Karlsson, Mats O ...
Simonsson, Ulrik ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Pharmaceutical S ...
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Journal of Pharm ...
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Uppsala University
Karolinska Institutet

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