[(3)H]Tiagabine binding to GABA transporter-1 (GAT-1) in suicidal depression.

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Fältnamn	Indikatorer	Metadata
000		01891naa a2200241 4500
001		oai:DiVA.org:umu-36480
003		SwePub
008		100930s2002 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-364802 URI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Sundman-Eriksson, Ingridu Umeå universitet,Psykiatri4 aut
245	1 0	a [(3)H]Tiagabine binding to GABA transporter-1 (GAT-1) in suicidal depression.
264	1	c 2002
338		a print2 rdacarrier
520		a BACKGROUND: In depressive disorders, alterations of GABA concentrations and number of postsynaptic GABA related receptor binding sites, as well as antidepressant effects exerted by GABA agonists, suggest a pathogenetic involvement of the GABA system. METHOD: The binding of the presynaptic GABA ligand [(3)H]tiagabine to GABA transporter-1 (GAT-1) was studied in post mortem human frontal cortex and cingulate gyrus from 13 suicide victims and 19 controls without known neurological or psychiatric disorder. RESULTS: No differences were found between the suicide victims and the controls with regard to the number of [(3)H]tiagabine binding sites (B(max)) or apparent affinity (K(d)). LIMITATIONS: The study was limited to two brain regions. CONCLUSION: Findings in other studies of alterations in the GABA system in depression seem according to the present results not to be associated with significant changes in the GABA uptake binding sites in the regions investigated.
700	1	a Allard, Peru Umeå universitet,Psykiatri4 aut0 (Swepub:umu)peal0001
710	2	a Umeå universitetb Psykiatri4 org
773	0	t Journal of Affective Disordersg 71:1-3, s. 29-33q 71:1-3<29-33x 0165-0327x 1573-2517
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36480

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