GABAergic control of dendritic calcium dynamics in striatal medium spiny neurons

Hjorth, Johannes (author)

Krieger, P (author)

Oliveira, R.F. (author)

Blackwell, Kim T (author)

(creator_code:org_t)

Related links:: https://doi.org/10.3...; show more...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Abstract Subject headings

Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites [1, 2, 3]. Increased calcium levels trigger changes in plasticity [4, 5], which is important for learning and other functions [6]. Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites [7]. The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of GABAergic inputs on the dendritic calcium dynamics is investigated.

By the author/editor: Hjorth, Johannes; Krieger, P; Oliveira, R.F.; Blackwell, Kim T; Hellgren Kotales ...

About the subject

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.