WFRF:(Brouwer P)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07114naa a2200937 4500 | |
| 001 | oai:lup.lub.lu.se:0d370abc-9e82-4e95-9ea2-4d115e7071fb | |
| 003 | SwePub | |
| 008 | 190701s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/0d370abc-9e82-4e95-9ea2-4d115e7071fb2 URI |
| 024 | 7 | a https://doi.org/10.1136/bmj.316.7135.8942 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Clarke, Robertu University of Oxford4 aut |
| 245 | 1 0 | a Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials |
| 264 | 1 | b BMJ,c 1998 |
| 520 | a Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentrations of different doses of folic acid and of the addition of vitamin B-12 or B-6. Subjects: Individual data on 1114 people included in 12 trials. Findings: The proportional and absolute reductions in blood homocysteine produced by folic acid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 μmol/l and of folate of 12 nmol/l (approximate average concentrations for Western populations), dietary folic acid reduced blood homocysteine concentrations by 25% (95% confidence interval 23% to 28%; P < 0.001), with similar effects in the range of 0.5-5 mg folic acid daily. Vitamin B-12 (mean 0.5 mg daily) produced an additional 7% (3% to 10%) reduction in blood homocysteine. Vitamin B-6 (mean 16.5 mg daily) did not have a significant additional effect. Conclusions: Typically in Western populations, daily supplementation with both 0.5-5 mg folic acid and about 0.5 mg vitamin B-12 would be expected to reduce blood homocysteine concentrations by about a quarter to a third (for example, from about 12 μmol/l to 8-9 μmol/l). Large scale randomised trials of such regimens in high risk populations are now needed to determine whether lowering blood homocysteine concentrations reduces the risk of vascular disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 700 | 1 | a Brattström, L.u Lund University4 aut |
| 700 | 1 | a Landgren, F.u Lund University4 aut |
| 700 | 1 | a Israelsson, B.u Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-bis |
| 700 | 1 | a Lindgren, A.u Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-ali |
| 700 | 1 | a Hultberg, B.u Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kkem-bhu |
| 700 | 1 | a Andersson, Au Lund University4 aut |
| 700 | 1 | a Cuskelly, G.u University of Ulster4 aut |
| 700 | 1 | a McNulty, H.u University of Ulster4 aut |
| 700 | 1 | a Strain, S. S.u University of Ulster4 aut |
| 700 | 1 | a McPartlin, J.u Trinity College Dublin4 aut |
| 700 | 1 | a Weir, D. G.u Trinity College Dublin4 aut |
| 700 | 1 | a Scott, J. M.u Trinity College Dublin4 aut |
| 700 | 1 | a den Heijer, H.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Brouwer, I. A.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Blom, H. J.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Bos, G. M.J.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Spaans, A.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Rosendaal, F. R.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Thomas, C. M.G.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Haak, H. L.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Wijermans, P. W.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Gerrits, W. B.J.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Naurath, H. J.u Catholic University of Leuven4 aut |
| 700 | 1 | a Joosten, E.u Catholic University of Leuven4 aut |
| 700 | 1 | a Riezler, R.u Catholic University of Leuven4 aut |
| 700 | 1 | a Stabler, S. P.u Catholic University of Leuven4 aut |
| 700 | 1 | a Allen, R. H.u Catholic University of Leuven4 aut |
| 700 | 1 | a Lindenbaum, J.u Catholic University of Leuven4 aut |
| 700 | 1 | a Pietrzik, K.u University of Bonn4 aut |
| 700 | 1 | a PrinzLangenohl, R.u University of Bonn4 aut |
| 700 | 1 | a Dierkes, J.u University of Bonn4 aut |
| 700 | 1 | a Saltzman, E.u Tufts University4 aut |
| 700 | 1 | a Mason, J. B.u Tufts University4 aut |
| 700 | 1 | a Jacques, P.u Tufts University4 aut |
| 700 | 1 | a Selhub, J.u Tufts University4 aut |
| 700 | 1 | a Salem, D.u Tufts University4 aut |
| 700 | 1 | a Schaefer, E.u Tufts University4 aut |
| 700 | 1 | a Rosenberg, I. H.u Tufts University4 aut |
| 700 | 1 | a Ubbink, J.u University of Pretoria4 aut |
| 700 | 1 | a van der Mere, A.u University of Pretoria4 aut |
| 700 | 1 | a Vermack, W. J.H.u University of Pretoria4 aut |
| 700 | 1 | a Delport, R.u University of Pretoria4 aut |
| 700 | 1 | a Becker, P. J.u University of Pretoria4 aut |
| 700 | 1 | a Potgieter, H. C.u University of Pretoria4 aut |
| 700 | 1 | a Woodside, J. V.u Queen's University Belfast4 aut |
| 700 | 1 | a Yarnell, J. W.G.u Queen's University Belfast4 aut |
| 700 | 1 | a McMaster, D.u Queen's University Belfast4 aut |
| 700 | 1 | a Young, I. S.u Queen's University Belfast4 aut |
| 700 | 1 | a McCrum, E. E.u Queen's University Belfast4 aut |
| 710 | 2 | a University of Oxfordb Lund University4 org |
| 710 | 2 | a Homocysteine Lowering Trialists' Collaboration |
| 773 | 0 | t British Medical Journald : BMJg 316:7135, s. 894-898q 316:7135<894-898x 0959-8146 |
| 773 | 0 | t BMJd : BMJg 316:7135, s. 894-898q 316:7135<894-898x 0959-8138x 1468-5833 |
| 856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28491/x freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1136/bmj.316.7135.894y FULLTEXT |
| 856 | 4 | u https://www.bmj.com/content/316/7135/894.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/0d370abc-9e82-4e95-9ea2-4d115e7071fb |
| 856 | 4 8 | u https://doi.org/10.1136/bmj.316.7135.894 |
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- Clarke, Robert
- Brattström, L.
- Landgren, F.
- Israelsson, B.
- Lindgren, A.
- Hultberg, B.
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- Andersson, A
- Cuskelly, G.
- McNulty, H.
- Strain, S. S.
- McPartlin, J.
- Weir, D. G.
- Scott, J. M.
- den Heijer, H.
- Brouwer, I. A.
- Blom, H. J.
- Bos, G. M.J.
- Spaans, A.
- Rosendaal, F. R.
- Thomas, C. M.G.
- Haak, H. L.
- Wijermans, P. W.
- Gerrits, W. B.J.
- Naurath, H. J.
- Joosten, E.
- Riezler, R.
- Stabler, S. P.
- Allen, R. H.
- Lindenbaum, J.
- Pietrzik, K.
- PrinzLangenohl, ...
- Dierkes, J.
- Saltzman, E.
- Mason, J. B.
- Jacques, P.
- Selhub, J.
- Salem, D.
- Schaefer, E.
- Rosenberg, I. H.
- Ubbink, J.
- van der Mere, A.
- Vermack, W. J.H.
- Delport, R.
- Becker, P. J.
- Potgieter, H. C.
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- Yarnell, J. W.G.
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