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  • Guo, JianqiuSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)

Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • Elsevier,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-75364
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75364URI
  • https://doi.org/10.1016/j.envpol.2019.05.040DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141361696URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:National Natural Science Foundation of China  NSFC-STINT 81611130087 Shanghai "3-Year Action" Project  GWIV-27.3 
  • Chlorpyrifos (CPF), an organophosphate insecticide, has been linked to adverse neurodevelopmental effects in animal studies. However, little is known about long-term neurotoxicity of early-life CPF exposure in humans. We aimed to evaluate the associations of both prenatal and early childhood CPF exposure with neurodevelopment of children. In this observational study based on Sheyang Mini Birth Cohort, pregnant women were recruited from an agricultural region between June 2009 and January 2010, and their children were followed up from birth to age three. Urinary 3,5,6-Trichloro-2-pyridinol (TCPy), a specific metabolite of CPF, was quantified using large-volume-injection gas chromatography tandem mass spectrometry. Developmental quotients (DQs) of children in motor, adaptive, language, and social areas were assessed by trained pediatricians. Data from 377 mother-child pairs were used in the current study. Associations between CPF exposure and neurodevelopmental indicators were estimated using generalized linear models with adjustment for potential confounders. The median concentrations of TCPy in maternal and children's urine were 5.39 mu g/L and 5.34 mu g/L, respectively. No statistically significant association was found between maternal urinary TCPy concentrations and children neurodevelopment. While for postnatal exposure, we found lower motor area DQ score 0.61 [95% confidence interval (CI): -1.13, -0.09; p = 0.02] and social area DQ score 0.55 (95% CI: -1.07, -0.03; p = 0.04) per one-unit increase in the In-transformed childhood urinary TCPy concentrations. Further stratification by sex indicated that the inverse associations were only observed in boys, but not in girls. Our findings suggest that adverse neurodevelopmental effects were associated with early childhood CPF exposure, but not prenatal exposure. Additional longitudinal studies are needed to replicate these results and to further understand the toxicological mechanisms of CPF.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhang, JimingSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Wu, ChunhuaSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Lv, ShenliangSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Lu, DashengShanghai Municipal Center for Disease Control and Prevention, Shanghai, China (författare)
  • Qi, XiaojuanSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China;Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China (författare)
  • Jiang, ShuaiSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Feng, ChaoShanghai Municipal Center for Disease Control and Prevention, Shanghai, China (författare)
  • Yu, HaixingSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Liang, WeijiuChangning District Center for Disease Control and Prevention, Shanghai, China (författare)
  • Chang, XiuliSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Zhang, YubinSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • Xu, HaoChangning District Center for Disease Control and Prevention, Shanghai, China (författare)
  • Cao, Yang,Associate Professor,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics(Swepub:oru)yco (författare)
  • Wang, GuoquanShanghai Municipal Center for Disease Control and Prevention, Shanghai, China (författare)
  • Zhou, ZhijunSchool of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China (författare)
  • School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, ChinaShanghai Municipal Center for Disease Control and Prevention, Shanghai, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environmental Pollution: Elsevier251, s. 538-5460269-74911873-6424

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