Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations

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Karady, JuliaSemmelweis University,Massachusetts General Hospital (författare)

Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations

Artikel/kapitelEngelska2024

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2024

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LIBRIS-ID:oai:lup.lub.lu.se:f0f696ce-f40b-4edc-a374-a09a1071e244
https://lup.lub.lu.se/record/f0f696ce-f40b-4edc-a374-a09a1071e244URI
https://doi.org/10.1016/j.jacadv.2024.100968DOI

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Språk:engelska
Sammanfattning på:engelska

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Background: People with HIV (PWH) have a high burden of coronary plaques; however, the comparison to people without known HIV (PwoH) needs clarification. Objectives: The purpose of this study was to determine coronary plaque burden/phenotype in PWH vs PwoH. Methods: Nonstatin using participants from 3 contemporary populations without known coronary plaques with coronary CT were compared: the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) studying PWH without cardiovascular symptoms at low-to-moderate risk (n = 755); the SCAPIS (Swedish Cardiopulmonary Bioimage Study) of asymptomatic community PwoH at low-to-intermediate cardiovascular risk (n = 23,558); and the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) of stable chest pain PwoH (n = 2,291). The coronary plaque prevalence on coronary CT was compared, and comparisons were stratified by 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and coronary artery calcium (CAC) presence. Results: Compared to SCAPIS and PROMISE PwoH, REPRIEVE PWH were younger (50.8 ± 5.8 vs 57.3 ± 4.3 and 60.0 ± 8.0 years; P < 0.001) and had lower ASCVD risk (5.0% ± 3.2% vs 6.0% ± 5.3% and 13.5% ± 11.0%; P < 0.001). More PWH had plaque compared to the asymptomatic cohort (48.5% vs 40.3%; P < 0.001). When stratified by ASCVD risk, PWH had more plaque compared to SCAPIS and a similar prevalence of plaque compared to PROMISE. CAC = 0 was more prevalent in PWH (REPRIEVE 65.2%; SCAPIS 61.6%; PROMISE 49.6%); among CAC = 0, plaque was more prevalent in PWH compared to the PwoH cohorts (REPRIEVE 20.8%; SCAPIS 5.4%; PROMISE 12.3%, P < 0.001). Conclusions: Asymptomatic PWH in REPRIEVE had more plaque than asymptomatic PwoH in SCAPIS but had similar prevalence to a higher-risk stable chest pain cohort in PROMISE. In PWH, CAC = 0 does not reliably exclude plaque.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
asymptomatic community cohort
cardiovascular disease
coronary CT angiography
coronary plaque
people with HIV
stable chest pain

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lu, Michael T.Massachusetts General Hospital (författare)
Bergström, GöranSahlgrenska Academy,Sahlgrenska University Hospital (författare)
Mayrhofer, ThomasMassachusetts General Hospital,University of Applied Sciences Stralsund (författare)
Taron, JanaUniversity Medical Center Freiburg,Massachusetts General Hospital (författare)
Foldyna, BorekMassachusetts General Hospital (författare)
Paradis, KaylaMassachusetts General Hospital (författare)
McCallum, SaraMassachusetts General Hospital (författare)
Aberg, Judith A.Icahn School of Medicine at Mount Sinai (författare)
Currier, Judith S.University of California, Los Angeles (författare)
Fitch, Kathleen V.Massachusetts General Hospital (författare)
Fulda, Evelynne S.Massachusetts General Hospital (författare)
Bloomfield, Gerald S.Duke Clinical Research Institute (DCRI) (författare)
Overton, Edgar T. (författare)
Lind, LarsUppsala University (författare)
Östgren, Carl JohanLinköping University (författare)
Elvstam, OlofLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Växjö Central Hospital(Swepub:lu)ol8873el (författare)
Söderberg, StefanUmeå University (författare)
Jernberg, TomasDanderyd Hospital (författare)
Pepe, RosalieCooper University Hospital, Camden (författare)
Dubé, Michael P.University of Southern California (författare)
Mushatt, DavidTulane University School of Medicine (författare)
Fichtenbaum, Carl J.University of Cincinnati (författare)
Malvestutto, CarlosOhio State University (författare)
Zanni, Markella V.Massachusetts General Hospital (författare)
Hoffmann, UdoMassachusetts General Hospital (författare)
Ribaudo, Heather (författare)
Grinspoon, Steven K.Massachusetts General Hospital (författare)
Douglas, Pamela S.Duke Clinical Research Institute (DCRI) (författare)
Semmelweis UniversityMassachusetts General Hospital (creator_code:org_t)

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Ingår i:JACC: Advances3:62772-963X

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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