Sökning: WFRF:(Gruber W) > (2020-2024) > Genome-wide interac...
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000 | 20751naa a2201465 4500 | |
001 | oai:DiVA.org:umu-214758 | |
003 | SwePub | |
008 | 231002s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:155073743 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2147582 URI |
024 | 7 | a https://doi.org/10.1016/j.ajcnut.2023.08.0102 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1550737432 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bouras, Emmanouilu Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut |
245 | 1 0 | a Genome-wide interaction analysis of folate for colorectal cancer risk |
264 | 1 | b Elsevier,c 2023 |
338 | a electronic2 rdacarrier | |
520 | a Background: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate's role in CRC.Objectives: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk.Methods: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO).Results: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10-8) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10-8). No interactions were observed for dietary and total folate.Conclusions: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a colorectal cancer | |
653 | a CRC | |
653 | a European | |
653 | a folate | |
653 | a folic acid | |
653 | a genome-wide | |
653 | a GWIS | |
653 | a interaction | |
653 | a SYN2 | |
653 | a synapsin | |
653 | a TIMP4 | |
653 | a tissue inhibitor of metalloproteinase 4 | |
700 | 1 | a Kim, Andre E.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Morrison, Johnu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Du, Mengmengu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, New York, United States4 aut |
700 | 1 | a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut |
700 | 1 | a Barry, Elizabeth L.u Department of Epidemiology, Geisel School of Medicine at Dartmouth, NH, Hanover, United States4 aut |
700 | 1 | a Baurley, James W.u Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; BioRealm LLC, CA, Walnut, United States4 aut |
700 | 1 | a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut |
700 | 1 | a Bien, Stephanie A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Bishop, Timothy D.u Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom4 aut |
700 | 1 | a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Budiarto, Arifu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Burnett-Hartman, Andreau Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States4 aut |
700 | 1 | a Campbell, Peter T.u Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States4 aut |
700 | 1 | a Carreras-Torres, Robertu Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain4 aut |
700 | 1 | a Casey, Grahamu Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States4 aut |
700 | 1 | a Cenggoro, Tjeng Wawanu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Chan, Andrew T.u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States4 aut |
700 | 1 | a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany4 aut |
700 | 1 | a Conti, David V.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Cotterchio, Michelleu Ontario Health (Cancer Care Ontario), ON, Toronto, Canada4 aut |
700 | 1 | a Devall, Matthewu Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States; Department of Public Health Sciences, Center for Public Health Genomics, VA, Charlottesville, United States4 aut |
700 | 1 | a Diez-Obrero, Virginiau Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain4 aut |
700 | 1 | a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Drew, David A.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut |
700 | 1 | a Figueiredo, Jane C.u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States4 aut |
700 | 1 | a Giles, Graham G.u Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia4 aut |
700 | 1 | a Gruber, Stephen B.u Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States4 aut |
700 | 1 | a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Hidaka, Akihisau Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Joshi, Amit D.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States4 aut |
700 | 1 | a Kawaguchi, Eric S.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, Los Angeles, United States4 aut |
700 | 1 | a Keku, Temitope O.u Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States4 aut |
700 | 1 | a Kundaje, Anshulu Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut |
700 | 1 | a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut |
700 | 1 | a Lewinger, Juan Pablou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Li, Liu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States4 aut |
700 | 1 | a Lynch, Brigid M.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia4 aut |
700 | 1 | a Mahesworo, Bharunou Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Männistö, Satuu Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland4 aut |
700 | 1 | a Moreno, Victoru Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain4 aut |
700 | 1 | a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States4 aut |
700 | 1 | a Obón-Santacana, Mireiau Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut |
700 | 1 | a Ose, Jenniferu Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
700 | 1 | a Palmer, Julie R.u Slone Epidemiology Center at Boston University, MA, Boston, United States4 aut |
700 | 1 | a Papadimitriou, Nikosu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Pardamean, Bensu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Pellatt, Andrew J.u Department of Cancer Medicine, MD Anderson Cancer Center, TX, Houston, United States4 aut |
700 | 1 | a Peoples, Anita R.u Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
700 | 1 | a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut |
700 | 1 | a Potter, John D.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand4 aut |
700 | 1 | a Qi, Lihongu Department of Public Health Sciences, University of California Davis, CA, Davis, United States4 aut |
700 | 1 | a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel4 aut |
700 | 1 | a Ruiz-Narvaez, Edwardu Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States4 aut |
700 | 1 | a Sakoda, Lori C.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States4 aut |
700 | 1 | a Schmit, Stephanie L.u Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States4 aut |
700 | 1 | a Shcherbina, Annau Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut |
700 | 1 | a Stern, Mariana C.u Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Su, Yu-Ruu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Tangen, Catherine M.u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Thomas, Duncan C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Tian, Yuu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China4 aut |
700 | 1 | a Um, Caroline Y.u Department of Population Science, American Cancer Society, GA, Atlanta, United States4 aut |
700 | 1 | a van Duijnhoven, Franzel JB.u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands4 aut |
700 | 1 | a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99 |
700 | 1 | a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut |
700 | 1 | a Wang, Junu Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet4 aut |
700 | 1 | a Woods, Michael O.u Memorial University of Newfoundland, Discipline of Genetics, St John's, Canada4 aut |
700 | 1 | a Ulrich, Cornelia M.u Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
700 | 1 | a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut |
700 | 1 | a Gauderman, W Jamesu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States4 aut |
700 | 1 | a Tsilidis, Konstantinos K.u Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom4 aut |
710 | 2 | a Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greeceb Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 org |
773 | 0 | t American Journal of Clinical Nutritiond : Elsevierg 118:5, s. 881-891q 118:5<881-891x 0002-9165x 1938-3207 |
856 | 4 | u https://doi.org/10.1016/j.ajcnut.2023.08.010y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1801512/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214758 |
856 | 4 8 | u https://doi.org/10.1016/j.ajcnut.2023.08.010 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:155073743 |
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