Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Guiducci C.) > Plasma HDL choleste...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		09581naa a2201885 4500
001		oai:DiVA.org:uu-223053
003		SwePub
008		140416s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:125062189
009		oai:lup.lub.lu.se:8618e123-43cb-463a-8012-8c056d31bebd
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2230532 URI
024	7	a https://doi.org/10.1016/S0140-6736(12)60312-22 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1250621892 URI
024	7	a https://lup.lub.lu.se/record/30695362 URI
040		a (SwePub)uud (SwePub)kid (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Voight, Benjamin F4 aut
245	1 0	a Plasma HDL cholesterol and risk of myocardial infarction :b a mendelian randomisation study
264	1	c 2012
338		a print2 rdacarrier
520		a BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Second, we used as an instrument a genetic score consisting of 14 common SNPs that exclusively associate with HDL cholesterol and tested this score in up to 12,482 cases of myocardial infarction and 41,331 controls. As a positive control, we also tested a genetic score of 13 common SNPs exclusively associated with LDL cholesterol.FINDINGS: Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10(-13)) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers. This difference in HDL cholesterol is expected to decrease risk of myocardial infarction by 13% (odds ratio [OR] 0·87, 95% CI 0·84-0·91). However, we noted that the 396Ser allele was not associated with risk of myocardial infarction (OR 0·99, 95% CI 0·88-1·11, p=0·85). From observational epidemiology, an increase of 1 SD in HDL cholesterol was associated with reduced risk of myocardial infarction (OR 0·62, 95% CI 0·58-0·66). However, a 1 SD increase in HDL cholesterol due to genetic score was not associated with risk of myocardial infarction (OR 0·93, 95% CI 0·68-1·26, p=0·63). For LDL cholesterol, the estimate from observational epidemiology (a 1 SD increase in LDL cholesterol associated with OR 1·54, 95% CI 1·45-1·63) was concordant with that from genetic score (OR 2·13, 95% CI 1·69-2·69, p=2×10(-10)).INTERPRETATION: Some genetic mechanisms that raise plasma HDL cholesterol do not seem to lower risk of myocardial infarction. These data challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Peloso, Gina M4 aut
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Frikke-Schmidt, Ruth4 aut
700	1	a Barbalic, Maja4 aut
700	1	a Jensen, Majken K4 aut
700	1	a Hindy, George4 aut
700	1	a Hólm, Hilma4 aut
700	1	a Ding, Eric L4 aut
700	1	a Johnson, Toby4 aut
700	1	a Schunkert, Heribert4 aut
700	1	a Samani, Nilesh J4 aut
700	1	a Clarke, Robert4 aut
700	1	a Hopewell, Jemma C4 aut
700	1	a Thompson, John F4 aut
700	1	a Li, Mingyao4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Newton-Cheh, Christopher4 aut
700	1	a Musunuru, Kiran4 aut
700	1	a Pirruccello, James P4 aut
700	1	a Saleheen, Danish4 aut
700	1	a Chen, Li4 aut
700	1	a Stewart, Alexandre F R4 aut
700	1	a Schillert, Arne4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Thorgeirsson, Gudmundur4 aut
700	1	a Anand, Sonia4 aut
700	1	a Engert, James C4 aut
700	1	a Morgan, Thomas4 aut
700	1	a Spertus, John4 aut
700	1	a Stoll, Monika4 aut
700	1	a Berger, Klaus4 aut
700	1	a Martinelli, Nicola4 aut
700	1	a Girelli, Domenico4 aut
700	1	a McKeown, Pascal P4 aut
700	1	a Patterson, Christopher C4 aut
700	1	a Epstein, Stephen E4 aut
700	1	a Devaney, Joseph4 aut
700	1	a Burnett, Mary-Susan4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Surakka, Ida4 aut
700	1	a Nieminen, Markku S4 aut
700	1	a Sinisalo, Juha4 aut
700	1	a Lokki, Marja-Liisa4 aut
700	1	a Perola, Markus4 aut
700	1	a Havulinna, Aki4 aut
700	1	a de Faire, Ulfu Karolinska Institutet4 aut
700	1	a Gigante, Brunau Karolinska Institutet4 aut
700	1	a Ingelsson, Erik,d 1975-u Karolinska Institutet4 aut0 (Swepub:uu)ering425
700	1	a Zeller, Tanja4 aut
700	1	a Wild, Philipp4 aut
700	1	a de Bakker, Paul I W4 aut
700	1	a Klungel, Olaf H4 aut
700	1	a Maitland-van der Zee, Anke-Hilse4 aut
700	1	a Peters, Bas J M4 aut
700	1	a de Boer, Anthonius4 aut
700	1	a Grobbee, Diederick E4 aut
700	1	a Kamphuisen, Pieter W4 aut
700	1	a Deneer, Vera H M4 aut
700	1	a Elbers, Clara C4 aut
700	1	a Onland-Moret, N Charlotte4 aut
700	1	a Hofker, Marten H4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Verschuren, W M Monique4 aut
700	1	a Boer, Jolanda M A4 aut
700	1	a van der Schouw, Yvonne T4 aut
700	1	a Rasheed, Asif4 aut
700	1	a Frossard, Philippe4 aut
700	1	a Demissie, Serkalem4 aut
700	1	a Willer, Cristen4 aut
700	1	a Do, Ron4 aut
700	1	a Ordovas, Jose M4 aut
700	1	a Abecasis, Gonçalo R4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Daly, Mark J4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Burtt, Noël P4 aut
700	1	a Surti, Aarti4 aut
700	1	a Gonzalez, Elena4 aut
700	1	a Purcell, Shaun4 aut
700	1	a Gabriel, Stacey4 aut
700	1	a Marrugat, Jaume4 aut
700	1	a Peden, John4 aut
700	1	a Erdmann, Jeanette4 aut
700	1	a Diemert, Patrick4 aut
700	1	a Willenborg, Christina4 aut
700	1	a König, Inke R4 aut
700	1	a Fischer, Marcus4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Ziegler, Andreas4 aut
700	1	a Buysschaert, Ian4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Van de Werf, Frans4 aut
700	1	a Fox, Keith A4 aut
700	1	a El Mokhtari, Nour Eddine4 aut
700	1	a Rubin, Diana4 aut
700	1	a Schrezenmeir, Jürgen4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Schäfer, Arne4 aut
700	1	a Danesh, John4 aut
700	1	a Blankenberg, Stefan4 aut
700	1	a Roberts, Robert4 aut
700	1	a McPherson, Ruth4 aut
700	1	a Watkins, Hugh4 aut
700	1	a Hall, Alistair S4 aut
700	1	a Overvad, Kim4 aut
700	1	a Rimm, Eric4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Tybjaerg-Hansen, Anne4 aut
700	1	a Cupples, L Adrienne4 aut
700	1	a Reilly, Muredach P4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Mannucci, Pier M4 aut
700	1	a Ardissino, Diego4 aut
700	1	a Siscovick, David4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Stefansson, Kari4 aut
700	1	a O'Donnell, Christopher J4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Rader, Daniel J4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Schwartz, Stephen M4 aut
700	1	a Altshuler, David4 aut
700	1	a Kathiresan, Sekar4 aut
710	2	a Diabetes - kardiovaskulär sjukdomb Forskargrupper vid Lunds universitet4 org
773	0	t The Lancetg 380:9841, s. 572-580q 380:9841<572-580x 0140-6736x 1474-547X
856	4	u http://dx.doi.org/10.1016/S0140-6736(12)60312-2x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223053
856	4 8	u https://doi.org/10.1016/S0140-6736(12)60312-2
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:125062189
856	4 8	u https://lup.lub.lu.se/record/3069536

Hitta via bibliotek

The Lancet (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Voight, Benjamin ...; Peloso, Gina M; Orho-Melander, M ...; Frikke-Schmidt, ...; Barbalic, Maja; Jensen, Majken K; visa fler...; Hindy, George; Hólm, Hilma; Ding, Eric L; Johnson, Toby; Schunkert, Herib ...; Samani, Nilesh J; Clarke, Robert; Hopewell, Jemma ...; Thompson, John F; Li, Mingyao; Thorleifsson, Gu ...; Newton-Cheh, Chr ...; Musunuru, Kiran; Pirruccello, Jam ...; Saleheen, Danish; Chen, Li; Stewart, Alexand ...; Schillert, Arne; Thorsteinsdottir ...; Thorgeirsson, Gu ...; Anand, Sonia; Engert, James C; Morgan, Thomas; Spertus, John; Stoll, Monika; Berger, Klaus; Martinelli, Nico ...; Girelli, Domenic ...; McKeown, Pascal ...; Patterson, Chris ...; Epstein, Stephen ...; Devaney, Joseph; Burnett, Mary-Su ...; Mooser, Vincent; Ripatti, Samuli; Surakka, Ida; Nieminen, Markku ...; Sinisalo, Juha; Lokki, Marja-Lii ...; Perola, Markus; Havulinna, Aki; de Faire, Ulf; Gigante, Bruna; Ingelsson, Erik, ...; Zeller, Tanja; Wild, Philipp; de Bakker, Paul ...; Klungel, Olaf H; Maitland-van der ...; Peters, Bas J M; de Boer, Anthoni ...; Grobbee, Diederi ...; Kamphuisen, Piet ...; Deneer, Vera H M; Elbers, Clara C; Onland-Moret, N ...; Hofker, Marten H; Wijmenga, Cisca; Verschuren, W M ...; Boer, Jolanda M ...; van der Schouw, ...; Rasheed, Asif; Frossard, Philip ...; Demissie, Serkal ...; Willer, Cristen; Do, Ron; Ordovas, Jose M; Abecasis, Gonçal ...; Boehnke, Michael; Mohlke, Karen L; Daly, Mark J; Guiducci, Candac ...; Burtt, Noël P; Surti, Aarti; Gonzalez, Elena; Purcell, Shaun; Gabriel, Stacey; Marrugat, Jaume; Peden, John; Erdmann, Jeanett ...; Diemert, Patrick; Willenborg, Chri ...; König, Inke R; Fischer, Marcus; Hengstenberg, Ch ...; Ziegler, Andreas; Buysschaert, Ian; Lambrechts, Diet ...; Van de Werf, Fra ...; Fox, Keith A; El Mokhtari, Nou ...; Rubin, Diana; Schrezenmeir, Jü ...; Schreiber, Stefa ...; Schäfer, Arne; Danesh, John; Blankenberg, Ste ...; Roberts, Robert; McPherson, Ruth; Watkins, Hugh; Hall, Alistair S; Overvad, Kim; Rimm, Eric; Boerwinkle, Eric; Tybjaerg-Hansen, ...; Cupples, L Adrie ...; Reilly, Muredach ...; Melander, Olle; Mannucci, Pier M; Ardissino, Diego; Siscovick, David; Elosua, Roberto; Stefansson, Kari; O'Donnell, Chris ...; Salomaa, Veikko; Rader, Daniel J; Peltonen, Leena; Schwartz, Stephe ...; Altshuler, David; Kathiresan, Seka ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: The Lancet

Av lärosätet: Uppsala universitet; Karolinska Institutet; Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se