WFRF:(Guo Kuo)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04582naa a2200697 4500 | |
| 001 | oai:DiVA.org:umu-161464 | |
| 003 | SwePub | |
| 008 | 190709s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:141143480 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1614642 URI |
| 024 | 7 | a https://doi.org/10.1111/all.137272 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1411434802 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kuo, Chih-Hsi S.4 aut |
| 245 | 1 0 | a Contribution of airway eosinophils in airway wall remodeling in asthma :b Role of MMP-10 and MET |
| 264 | c 2019-02-11 | |
| 264 | 1 | b John Wiley & Sons,c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a Background Eosinophils play an important role in the pathophysiology of asthma being implicated in airway epithelial damage and airway wall remodeling. We determined the genes associated with airway remodeling and eosinophilic inflammation in patients with asthma. Methods We analyzed the transcriptomic data from bronchial biopsies of 81 patients with moderate-to-severe asthma of the U-BIOPRED cohort. Expression profiling was performed using Affymetrix arrays on total RNA. Transcription binding site analysis used the PRIMA algorithm. Localization of proteins was by immunohistochemistry. Results Using stringent false discovery rate analysis, MMP-10 and MET were significantly overexpressed in biopsies with high mucosal eosinophils (HE) compared to low mucosal eosinophil (LE) numbers. Immunohistochemical analysis confirmed increased expression of MMP-10 and MET in bronchial epithelial cells and in subepithelial inflammatory and resident cells in asthmatic biopsies. Using less-stringent conditions (raw P-value < 0.05, log2 fold change > 0.5), we defined a 73-gene set characteristic of the HE compared to the LE group. Thirty-three of 73 genes drove the pathway annotation that included extracellular matrix (ECM) organization, mast cell activation, CC-chemokine receptor binding, circulating immunoglobulin complex, serine protease inhibitors, and microtubule bundle formation pathways. Genes including MET and MMP10 involved in ECM organization correlated positively with submucosal thickness. Transcription factor binding site analysis identified two transcription factors, ETS-1 and SOX family proteins, that showed positive correlation with MMP10 and MET expression. Conclusion Pathways of airway remodeling and cellular inflammation are associated with submucosal eosinophilia. MET and MMP-10 likely play an important role in these processes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 653 | a asthma | |
| 653 | a eosinophil | |
| 653 | a mast cell | |
| 653 | a MET | |
| 653 | a MMP10 | |
| 700 | 1 | a Pavlidis, Stelios4 aut |
| 700 | 1 | a Zhu, Jie4 aut |
| 700 | 1 | a Loza, Matthew4 aut |
| 700 | 1 | a Baribaud, Fred4 aut |
| 700 | 1 | a Rowe, Anthony4 aut |
| 700 | 1 | a Pandis, Ioannis4 aut |
| 700 | 1 | a Gibeon, David4 aut |
| 700 | 1 | a Hoda, Uruj4 aut |
| 700 | 1 | a Sousa, Ana4 aut |
| 700 | 1 | a Wilson, Susan J.4 aut |
| 700 | 1 | a Howarth, Peter4 aut |
| 700 | 1 | a Shaw, Dominick4 aut |
| 700 | 1 | a Fowler, Stephen4 aut |
| 700 | 1 | a Dahlen, Barbrou Karolinska Institutet4 aut |
| 700 | 1 | a Chanez, Pascal4 aut |
| 700 | 1 | a Krug, Norbert4 aut |
| 700 | 1 | a Sandström, Thomas,d 1957-u Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)thsa0001 |
| 700 | 1 | a Fleming, Louise4 aut |
| 700 | 1 | a Corfield, Julie4 aut |
| 700 | 1 | a Auffray, Charles4 aut |
| 700 | 1 | a Djukanovic, Ratko4 aut |
| 700 | 1 | a Sterk, Peter J.4 aut |
| 700 | 1 | a Guo, Yike4 aut |
| 700 | 1 | a Adcock, Ian M.4 aut |
| 700 | 1 | a Chung, Kian Fan4 aut |
| 710 | 2 | a Karolinska Institutetb Avdelningen för medicin4 org |
| 773 | 0 | t Allergy. European Journal of Allergy and Clinical Immunologyd : John Wiley & Sonsg 74:6, s. 1102-1112q 74:6<1102-1112x 0105-4538x 1398-9995 |
| 856 | 4 | u https://www.research.manchester.ac.uk/portal/files/85538534/Kuo_et_al_2019_Allergy.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161464 |
| 856 | 4 8 | u https://doi.org/10.1111/all.13727 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141143480 |
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- Pandis, Ioannis
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