Rapid, in-patient adaptations of Legionella pneumophila to the human host

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Fältnamn	Indikatorer	Metadata
000		03969nam a2200421 4500
001		oai:DiVA.org:uu-484648
003		SwePub
008		220915s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4846482 URI
024	7	a https://doi.org/10.1101/2022.05.23.4929812 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a ovr2 swepub-publicationtype
100	1	a Leenheer, Daniëlu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,University of Tsukuba4 aut0 (Swepub:uu)denle285
245	1 0	a Rapid, in-patient adaptations of Legionella pneumophila to the human host
264	1	b Cold Spring Harbor Laboratory,c 2024
338		a electronic2 rdacarrier
520		a Legionella pneumophila are host-adapted bacteria that infect and reproduce primarily in amoeboid protists. Using similar infection mechanisms, they infect human macrophages, and cause Legionnaires’ disease, an atypical pneumonia, and the milder Pontiac fever. We hypothesized that, despite these similarities, the hosts are different enough so that there exist high-selective value mutations that would dramatically increase the fitness of Legionella inside the human host. By comparing a large number of isolates from independent infections, we identified two genes, mutated in three unrelated patients, despite the short duration of the incubation period (2-14 days). One is a gene coding for an outer membrane protein (OMP) belonging to the OmpP1/FadL family. The clinical strain, carrying the mutated OMP homolog, grows faster in macrophages than the wild type strain, and thus appears to be better adapted to the human host. The other is a gene coding for a protein involved in cyclic-di-GMP regulation, which in turn modulates flagellar activity. As human-to-human transmission is very rare, fixation of these mutations into the population and spread into the environment is unlikely. Therefore, convergent evolution – here mutations in the same genes observed in independent human infections – could point to adaptations to the accidental human host. These results suggest that despite its ability to infect, replicate, and disperse from amoebae, L. pneumophila is not well adapted to the human host.
650	7	a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
650	7	a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653		a Biologi med inriktning mot mikrobiologi
653		a Biology with specialization in Microbiology
653		a Biologi med inriktning mot molekylär evolution
653		a Biology with specialization in Molecular Evolution
700	1	a Moreno, Anaisa B.u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)animo450
700	1	a Murray, Susanu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)susmu240
700	1	a Jarraud, Sophie4 aut
700	1	a Ginevra, Christophe4 aut
700	1	a Guy, Lionel,c PhD, Docent,d 1980-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)liogu139
710	2	a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org
856	4	u https://doi.org/10.1101/2022.05.23.492981y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1695946/FULLTEXT01.pdfx primaryx Raw objecty fulltext
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484648
856	4 8	u https://doi.org/10.1101/2022.05.23.492981

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Av författaren/redakt...: Leenheer, Daniël; Moreno, Anaisa B ...; Murray, Susan; Jarraud, Sophie; Ginevra, Christo ...; Guy, Lionel, PhD ...

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NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Evolutionsbiolog ...

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Mikrobiologi

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