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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 18491naa a2205209 4500 | |
| 001 | oai:gup.ub.gu.se/320866 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3208662 URI |
| 024 | 7 | a https://doi.org/10.1016/s2468-1253(22)00044-92 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Sharma, R.4 aut |
| 245 | 1 0 | a Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| 264 | 1 | b Elsevier BV,c 2022 |
| 520 | a Background Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990-2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408-868 574) to 2.17 million (2.00-2.34), and deaths increased from 518 126 (493 682-537 877) to 1.09 million (1.02-1.15). The global age-standardised incidence rate increased from 22.2 (95% UI 21.3-23.0) per 100 000 to 26.7 (24.6-28.9) per 100 000, whereas the age-standardised mortality rate decreased from 14.3 (13.5-14.9) per 100 000 to 13.7 (12.6-14.5) per 100 000 and the age-standardised DALY rate decreased from 308.5 (294.7-320.7) per 100 000 to 295.5 (275.2-313.0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62.0 [48.9-80.0] per 100 000), Monaco (60.7 [48.5-73.6] per 100 000), and Andorra (56.6 [42.8-71.9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31.4 [26.0-37.1] per 100 000), Brunei (30.3 [26.6-34.1] per 100 000), and Hungary (28.6 [23.6-34.0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age <50 years), particularly in high Socio-demographic Index (SDI) countries. Globally, a diet low in milk (15.6%), smoking (13.3%), a diet low in calcium (12.9%), and alcohol use (9.9%) were the main contributors to colorectal cancer DALYs in 2019. Interpretation The increase in incidence rates in people younger than 50 years requires vigilance from researchers, clinicians, and policy makers and a possible reconsideration of screening guidelines. The fast-rising burden in low SDI and middle SDI countries in Asia and Africa calls for colorectal cancer prevention approaches, greater awareness, and cost-effective screening and therapeutic options in these regions. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a gender | |
| 653 | a disparities | |
| 653 | a hereditary | |
| 653 | a mortality | |
| 653 | a survival | |
| 653 | a impact | |
| 653 | a colon | |
| 653 | a sex | |
| 653 | a Gastroenterology & Hepatology | |
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| 700 | 1 | a Miao Jonasson, Junmei,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xmiaoj |
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| 700 | 1 | a Ullah, I.4 aut |
| 700 | 1 | a Ullah, S.4 aut |
| 700 | 1 | a Vacante, M.4 aut |
| 700 | 1 | a Tahbaz, S. V.4 aut |
| 700 | 1 | a Veroux, M.4 aut |
| 700 | 1 | a Vo, B.4 aut |
| 700 | 1 | a Vos, T.4 aut |
| 700 | 1 | a Wang, C.4 aut |
| 700 | 1 | a Westerman, R.4 aut |
| 700 | 1 | a Woldemariam, M.4 aut |
| 700 | 1 | a Jabbari, S. H. Y.4 aut |
| 700 | 1 | a Yang, L.4 aut |
| 700 | 1 | a Yazdanpanah, F.4 aut |
| 700 | 1 | a Yu, C. H.4 aut |
| 700 | 1 | a Yuce, D.4 aut |
| 700 | 1 | a Yunusa, I.4 aut |
| 700 | 1 | a Zadnik, V.4 aut |
| 700 | 1 | a Zahir, M.4 aut |
| 700 | 1 | a Zare, I.4 aut |
| 700 | 1 | a Zhang, Z. J.4 aut |
| 700 | 1 | a Zoladi, M.4 aut |
| 700 | 1 | a G. B. D. Colorectal Canc Collabora, G. B. D. Colorectal Canc Collabora4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org |
| 773 | 0 | t Lancet Gastroenterology & Hepatologyd : Elsevier BVg 7:7, s. 627-647q 7:7<627-647x 2468-1253 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/320866 |
| 856 | 4 8 | u https://doi.org/10.1016/s2468-1253(22)00044-9 |
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