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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005569naa a2200613 4500
001oai:DiVA.org:umu-127668
003SwePub
008161117s2017 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-361224
009oai:prod.swepub.kib.ki.se:135959463
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1276682 URI
0247 a https://doi.org/10.1007/s00345-016-1952-x2 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3612242 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1359594632 URI
040 a (SwePub)umud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rosenblatt, Robertu Umeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden4 aut0 (Swepub:umu)roro0025
2451 0a Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report
264 c 2016-10-13
264 1b Springer Science and Business Media LLC,c 2017
338 a electronic2 rdacarrier
520 a PURPOSE: To determine whether sentinel node detection (SNd) in muscle-invasive urothelial bladder cancer (MIBC) can be performed in patients undergoing neoadjuvant chemotherapy (NAC) and determine whether SNd is feasible in all pT stages, including pT0.BACKGROUND: Previous published series of SNd in MIBC have not included patients undergoing NAC, and systematic reports of pT0 patients w/wo NAC were absent. Translational immunological tumor research on MIBC focusing on SNd, in the era of NAC, requires technical feasibility. Additionally, SNd in MIBC requests further evaluations as a method for nodal staging.MATERIALS AND METHODS: Ninety-nine patients with suspected urothelial MIBC were prospectively selected from six urological centers. After TUR-B and primary staging, 65 MIBC patients qualified for radical cystectomy. Precystectomy staging was cT2a-T4aN0M0, including 47 NAC patients and 18 chemo-naïve patients. All 65 patients underwent intraoperative SNd by peritumoral injection of 80 Mbq Technetium and Geiger probe detection. Postcystectomy staging was pT0-T4aN0-N2M0. SNs were defined by two calculations, SNdef1 and SNdef2.RESULTS: Totally 1063 lymph nodes were removed (total SNs; 222-227). NAC patients with pT0 (n = 24) displayed a true positive detection in 91.7 % by either SNdef, with a median of 3.0 SNs. NACpT >0 patients had a true positive detection in 87 % (SNdef1) and 91.3 % (SNdef2). In a univariate analysis, patient group neither NAC nor tumor downstaging influenced detection rates, regardless of SN definition. In total eight patients, 4/22 metastatic nodes were SNs while 18/22 were non-SNs.CONCLUSIONS: Sentinel node detection in MIBC is feasible also in NAC patients, regardless of pT stage. SNd played no role in nodal staging.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Urinary bladder neoplasms
653 a Neoadjuvant therapy
653 a Cisplatin
653 a Sentinel lymph node biopsy
653 a Cystectomy
653 a Immunotherapy
7001 a Johansson, Markusu Sundsvall Hosp, Dept Urol, Sundsvall, Sweden4 aut
7001 a Alamdari, Farhoodu Vastmanland Hosp, Dept Urol, Vasteras, Sweden4 aut
7001 a Sidiki, Alexanderu Lanssjukhuset Ryhov, Dept Urol, Jonkoping, Sweden4 aut
7001 a Holmström, Bennyu Uppsala universitet,Urologkirurgi4 aut
7001 a Hansson, Johan,d 1964-u Uppsala universitet,Centrum för klinisk forskning, Gävleborg4 aut0 (Swepub:uu)johan031
7001 a Vasko, Janosu Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden4 aut0 (Swepub:umu)jasvao04
7001 a Marits, Peru Karolinska Institutet4 aut
7001 a Gabrielsson, Susanneu Karolinska Institutet4 aut
7001 a Riklund, Katrineu Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden4 aut0 (Swepub:umu)kaah0001
7001 a Winqvist, Olau Karolinska Institutet4 aut
7001 a Sherif, Amiru Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden4 aut0 (Swepub:umu)amsh0008
7102 a Umeå universitetb Urologi och andrologi4 org
7730 t World journal of urologyd : Springer Science and Business Media LLCg 35:6, s. 921-927q 35:6<921-927x 0724-4983x 1433-8726
8564 u https://doi.org/10.1007/s00345-016-1952-xy Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1047212/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007%2Fs00345-016-1952-x.pdf
8564 u https://uu.diva-portal.org/smash/get/diva2:1250907/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127668
8564 8u https://doi.org/10.1007/s00345-016-1952-x
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361224
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135959463

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