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Inflammatory potent...
Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study
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- Jakszyn, Paula (författare)
- Bellvitge University Hospital-IDIBELL,Ramon Llull University
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- Cayssials, Valerie (författare)
- Bellvitge University Hospital-IDIBELL
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- Buckland, Genevieve (författare)
- University of Bristol
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- Perez-Cornago, Aurora (författare)
- University of Oxford
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Bergmann, Manuela M. (författare)
- German Institute of Human Nutrition
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- Vulcan, Alexandra (författare)
- Skåne University Hospital
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- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Cross, Amanda J. (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Ricceri, Fulvio (författare)
- Azienda Sanitaria Locale Torino 3,Citta' della Salute e della Scienza Hospital-University of Turin
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- Dahm, Christina C. (författare)
- Aarhus University
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- Nyvang, Dorthe (författare)
- Aarhus University
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- Katzke, Verena A. (författare)
- German Cancer Research Centre
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Kyrø, Cecilie (författare)
- Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Ward, Heather A. (författare)
- University of Ioannina,Imperial College London
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- Tsilidis, Konstantinos K. (författare)
- University of Ioannina,Imperial College London
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø,University of Leeds
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- Sieri, Sabina (författare)
- Istituto Nazionale dei Tumori
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- Sanchez, Maria Jose (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada
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- Huerta, Jose M. (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Amiano, Pilar (författare)
- Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Lasheras, Cristina (författare)
- University of Oviedo
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- Ardanaz, Eva (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Mahamat-Saleh, Yahya (författare)
- Stabilite genetique et oncogenese,University of Paris-Saclay
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- Boutron-Ruault, Marie Christine (författare)
- Stabilite genetique et oncogenese,University of Paris-Saclay
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- Carbonnel, Franck (författare)
- University of Paris-Saclay,Bicêtre Hospital,Stabilite genetique et oncogenese
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Vermeulen, Roel (författare)
- University Medical Center Utrecht,Utrecht University
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc (författare)
- International Agency for Research on Cancer, World Health Organization
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- Agudo, Antonio (författare)
- Bellvitge University Hospital-IDIBELL
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(creator_code:org_t)
- 2020-01-31
- 2020
- Engelska 13 s.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 147:4, s. 1027-1039
- Relaterad länk:
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http://dx.doi.org/10...
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https://research-inf...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04–1.27) for CRC, 1.24 (95% CI 1.09–1.41) for colon cancer and 0.99 (95% CI 0.83–1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31–2.01) for colon cancer overall and 2.11 (95% CI 1.50–2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- association
- colorectal cancer
- epidemiology
- Europe
- inflammatory potential of the diet
- prospective cohort
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- art (ämneskategori)
- ref (ämneskategori)
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Jakszyn, Paula
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Cayssials, Valer ...
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Buckland, Genevi ...
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Perez-Cornago, A ...
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Weiderpass, Elis ...
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Boeing, Heiner
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visa fler...
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Bergmann, Manuel ...
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Vulcan, Alexandr ...
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Ohlsson, Bodil
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Masala, Giovanna
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Cross, Amanda J.
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Riboli, Elio
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Ricceri, Fulvio
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Dahm, Christina ...
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Nyvang, Dorthe
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Katzke, Verena A ...
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Kühn, Tilman
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Kyrø, Cecilie
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Tjønneland, Anne
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Ward, Heather A.
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Tsilidis, Konsta ...
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Skeie, Guri
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Sieri, Sabina
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Sanchez, Maria J ...
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Huerta, Jose M.
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Amiano, Pilar
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Lasheras, Cristi ...
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Ardanaz, Eva
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Mahamat-Saleh, Y ...
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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Panico, Salvator ...
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Peppa, Eleni
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Tumino, Rosario
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Vermeulen, Roel
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Jenab, Mazda
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Gunter, Marc
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Agudo, Antonio
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