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  • Sjöberg, Sara,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (författare)

CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient mice

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • Elsevier,2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:his-11379
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11379URI
  • https://doi.org/10.1016/j.atherosclerosis.2009.03.002DOI
  • https://gup.ub.gu.se/publication/95492URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119538653URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVE: Vascular and inflammatory cells express adhesion molecule CD44. We demonstrated previously that enhanced CD44 localizes in human atherosclerotic lesions. Apolipoprotein E/cd44 double-deficient mice and apolipoprotein E-deficient mice transplanted with CD44-deficient bone marrow (BM) exhibit reduced atherosclerosis. Since CD44 is a novel factor in atherogenesis, it is imperative that it is investigated in more than one animal model to conclusively determine its role in this particular disease pathology. To test the hypothesis that CD44 expressed by hematopoietic cells plays a critical role in atherogenesis in the low density lipoprotein (LDL) receptor-deficient mouse model, we performed BM reconstitution experiments.METHODS: Lethally irradiated LDL receptor-deficient mice were transplanted with either CD44-deficient or wild-type BM. Beginning 10 weeks after successful reconstitution, mice consumed a cholesterol-enriched atherogenic diet for 6 or 11 weeks.RESULTS: Surprisingly, CD44-deficiency on BM-derived inflammatory cells did not affect lesion size. Additionally, neither group displayed differences in smooth muscle cell, macrophage, collagen, or elastin content as well as lipoprotein levels. However, lesions in CD44-deficient BM-recipient mice contained fewer T-cells compared to wild-type BM mice. Interestingly, CD44-deficient T-cells expressed less chemokine receptor-5 mRNA. Furthermore, in vivo leukocyte adhesion decreased in CD44-deficient mice compared to wild-type mice.CONCLUSION: This study surprisingly revealed that atherogenesis does not require CD44 expression on hematopoietic cells in the LDL receptor-deficient mouse model. However, CD44 promotes T-cell recruitment, downregulates chemokine receptor-5, and participates critically in leukocyte adhesion in vivo. Consequently, the anti-atherogenic role of CD44 may require CD44-deficiency on cell types other than inflammatory cells in the LDL receptor-deficient mouse model.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Eriksson, Einar E.Karolinska Institutet,Dept. of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (författare)
  • Tivesten, Åsa,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xtivas (författare)
  • Carlsson, AnnelieGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xcanng (författare)
  • Klasson, AnnaWallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (författare)
  • Levin, Max,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xlevma (författare)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xborej (författare)
  • Krettek, Alexandra,1968-Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden / Nordic School of Public Health, Gothenburg, Sweden(Swepub:gu)xkreal (författare)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Atherosclerosis: Elsevier206:2, s. 369-3740021-91501879-1484

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