Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

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Fältnamn	Indikatorer	Metadata
000		07887naa a2201633 4500
001		oai:gup.ub.gu.se/228909
003		SwePub
008		240528s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2289092 URI
024	7	a https://doi.org/10.1093/hmg/ddv4722 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Felix, Janine F4 aut
245	1 0	a Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
264		c 2015-11-24
264	1	b Oxford University Press (OUP),c 2016
520		a A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
700	1	a Bradfield, Jonathan P4 aut
700	1	a Monnereau, Claire4 aut
700	1	a van der Valk, Ralf J P4 aut
700	1	a Stergiakouli, Evie4 aut
700	1	a Chesi, Alessandra4 aut
700	1	a Gaillard, Romy4 aut
700	1	a Feenstra, Bjarke4 aut
700	1	a Thiering, Elisabeth4 aut
700	1	a Kreiner-Møller, Eskil4 aut
700	1	a Mahajan, Anubha4 aut
700	1	a Pitkänen, Niina4 aut
700	1	a Joro, Raimo4 aut
700	1	a Cavadino, Alana4 aut
700	1	a Huikari, Ville4 aut
700	1	a Franks, Steve4 aut
700	1	a Groen-Blokhuis, Maria M4 aut
700	1	a Cousminer, Diana L4 aut
700	1	a Marsh, Julie A4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Curtin, John A4 aut
700	1	a Vioque, Jesus4 aut
700	1	a Ahluwalia, Tarunveer S4 aut
700	1	a Myhre, Ronny4 aut
700	1	a Price, Thomas S4 aut
700	1	a Vilor-Tejedor, Natalia4 aut
700	1	a Yengo, Loïc4 aut
700	1	a Grarup, Niels4 aut
700	1	a Ntalla, Ioanna4 aut
700	1	a Ang, Wei4 aut
700	1	a Atalay, Mustafa4 aut
700	1	a Bisgaard, Hans4 aut
700	1	a Blakemore, Alexandra I4 aut
700	1	a Bonnefond, Amelie4 aut
700	1	a Carstensen, Lisbeth4 aut
700	1	a Eriksson, Johan4 aut
700	1	a Flexeder, Claudia4 aut
700	1	a Franke, Lude4 aut
700	1	a Geller, Frank4 aut
700	1	a Geserick, Mandy4 aut
700	1	a Hartikainen, Anna-Liisa4 aut
700	1	a Haworth, Claire M A4 aut
700	1	a Hirschhorn, Joel N4 aut
700	1	a Hofman, Albert4 aut
700	1	a Holm, Jens-Christian4 aut
700	1	a Horikoshi, Momoko4 aut
700	1	a Hottenga, Jouke Jan4 aut
700	1	a Huang, Jinyan4 aut
700	1	a Kadarmideen, Haja N4 aut
700	1	a Kähönen, Mika4 aut
700	1	a Kiess, Wieland4 aut
700	1	a Lakka, Hanna-Maaria4 aut
700	1	a Lakka, Timo A4 aut
700	1	a Lewin, Alexandra M4 aut
700	1	a Liang, Liming4 aut
700	1	a Lyytikäinen, Leo-Pekka4 aut
700	1	a Ma, Baoshan4 aut
700	1	a Magnus, Per4 aut
700	1	a McCormack, Shana E4 aut
700	1	a McMahon, George4 aut
700	1	a Mentch, Frank D4 aut
700	1	a Middeldorp, Christel M4 aut
700	1	a Murray, Clare S4 aut
700	1	a Pahkala, Katja4 aut
700	1	a Pers, Tune H4 aut
700	1	a Pfäffle, Roland4 aut
700	1	a Postma, Dirkje S4 aut
700	1	a Power, Christine4 aut
700	1	a Simpson, Angela4 aut
700	1	a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve
700	1	a Tiesler, Carla M T4 aut
700	1	a Torrent, Maties4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a van Meurs, Joyce B4 aut
700	1	a Vinding, Rebecca4 aut
700	1	a Waage, Johannes4 aut
700	1	a Wardle, Jane4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Zemel, Babette S4 aut
700	1	a Dedoussis, George V4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Froguel, Philippe4 aut
700	1	a Sunyer, Jordi4 aut
700	1	a Plomin, Robert4 aut
700	1	a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo
700	1	a Hansen, Torben4 aut
700	1	a Gonzalez, Juan R4 aut
700	1	a Custovic, Adnan4 aut
700	1	a Raitakari, Olli T4 aut
700	1	a Pennell, Craig E4 aut
700	1	a Widén, Elisabeth4 aut
700	1	a Boomsma, Dorret I4 aut
700	1	a Koppelman, Gerard H4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Hyppönen, Elina4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Lindi, Virpi4 aut
700	1	a Harri, Niinikoski4 aut
700	1	a Körner, Antje4 aut
700	1	a Bønnelykke, Klaus4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Melbye, Mads4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Ring, Susan M4 aut
700	1	a Smith, George Davey4 aut
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Timpson, Nicholas J4 aut
700	1	a Grant, Struan F A4 aut
700	1	a Jaddoe, Vincent W V4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
773	0	t Human molecular geneticsd : Oxford University Press (OUP)g 25:2, s. 389-403q 25:2<389-403x 1460-2083x 0964-6906
856	4	u https://academic.oup.com/hmg/article-pdf/25/2/389/18526832/ddv472.pdf
856	4 8	u https://gup.ub.gu.se/publication/228909
856	4 8	u https://doi.org/10.1093/hmg/ddv472

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By the author/editor: Felix, Janine F; Bradfield, Jonat ...; Monnereau, Clair ...; van der Valk, Ra ...; Stergiakouli, Ev ...; Chesi, Alessandr ...; show more...; Gaillard, Romy; Feenstra, Bjarke; Thiering, Elisab ...; Kreiner-Møller, ...; Mahajan, Anubha; Pitkänen, Niina; Joro, Raimo; Cavadino, Alana; Huikari, Ville; Franks, Steve; Groen-Blokhuis, ...; Cousminer, Diana ...; Marsh, Julie A; Lehtimäki, Terho; Curtin, John A; Vioque, Jesus; Ahluwalia, Tarun ...; Myhre, Ronny; Price, Thomas S; Vilor-Tejedor, N ...; Yengo, Loïc; Grarup, Niels; Ntalla, Ioanna; Ang, Wei; Atalay, Mustafa; Bisgaard, Hans; Blakemore, Alexa ...; Bonnefond, Ameli ...; Carstensen, Lisb ...; Eriksson, Johan; Flexeder, Claudi ...; Franke, Lude; Geller, Frank; Geserick, Mandy; Hartikainen, Ann ...; Haworth, Claire ...; Hirschhorn, Joel ...; Hofman, Albert; Holm, Jens-Chris ...; Horikoshi, Momok ...; Hottenga, Jouke ...; Huang, Jinyan; Kadarmideen, Haj ...; Kähönen, Mika; Kiess, Wieland; Lakka, Hanna-Maa ...; Lakka, Timo A; Lewin, Alexandra ...; Liang, Liming; Lyytikäinen, Leo ...; Ma, Baoshan; Magnus, Per; McCormack, Shana ...; McMahon, George; Mentch, Frank D; Middeldorp, Chri ...; Murray, Clare S; Pahkala, Katja; Pers, Tune H; Pfäffle, Roland; Postma, Dirkje S; Power, Christine; Simpson, Angela; Sengpiel, Verena ...; Tiesler, Carla M ...; Torrent, Maties; Uitterlinden, An ...; van Meurs, Joyce ...; Vinding, Rebecca; Waage, Johannes; Wardle, Jane; Zeggini, Elefthe ...; Zemel, Babette S; Dedoussis, Georg ...; Pedersen, Oluf; Froguel, Philipp ...; Sunyer, Jordi; Plomin, Robert; Jacobsson, Bo, 1 ...; Hansen, Torben; Gonzalez, Juan R; Custovic, Adnan; Raitakari, Olli ...; Pennell, Craig E; Widén, Elisabeth; Boomsma, Dorret ...; Koppelman, Gerar ...; Sebert, Sylvain; Järvelin, Marjo- ...; Hyppönen, Elina; McCarthy, Mark I; Lindi, Virpi; Harri, Niinikosk ...; Körner, Antje; Bønnelykke, Klau ...; Heinrich, Joachi ...; Melbye, Mads; Rivadeneira, Fer ...; Hakonarson, Hako ...; Ring, Susan M; Smith, George Da ...; Sørensen, Thorki ...; Timpson, Nichola ...; Grant, Struan F ...; Jaddoe, Vincent ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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