Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications

Wang, Shujiang (author): Uppsala universitet,Institutionen för kemi - Ångström

Tavakoli, Shima (author): Uppsala universitet,Institutionen för kemi - Ångström

Parvathaneni, Rohith Pavan (author): Uppsala universitet,Institutionen för kemi - Ångström

Nawale, Ganesh N. (author): Uppsala universitet,Institutionen för kemi - Ångström

Oommen, Oommen P. (author): Tampere Univ, Fac Med & Hlth Technol, Bioengn & Nanomed Grp, Tampere 33720, Finland.

Hilborn, Jöns, 1956- (author): Uppsala universitet,Institutionen för kemi - Ångström

Varghese, Oommen P., 1977- (author): Uppsala universitet,Institutionen för kemi - Ångström

(creator_code:org_t)

2022
2022
English.
In: Biomaterials Science. - : Royal Society of Chemistry (RSC). - 2047-4830 .- 2047-4849. ; 10:22, s. 6399-6412

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Hyaluronic acid (HA), one of the main components of the extracellular matrix (ECM), is extensively used in the design of hydrogels and nanoparticles for different biomedical applications due to its critical role in vivo, degradability by endogenous enzymes, and absence of immunogenicity. HA-based hydrogels and nanoparticles have been developed by utilizing different crosslinking chemistries. The development of such crosslinking chemistries indicates that even subtle differences in the structure of reactive groups or the procedure of crosslinking may have a profound impact on the intended mechanical, physical and biological outcomes. There are widespread examples of modified HA polymers that can form either covalently or physically crosslinked biomaterials. More recently, studies have been focused on dynamic covalent crosslinked HA-based biomaterials since these types of crosslinking allow the preparation of dynamic structures with the ability to form in situ, be injectable, and have self-healing properties. In this review, HA-based hydrogels and nanomaterials that are crosslinked by dynamic-covalent coupling (DCC) chemistry have been critically assessed.

By the author/editor: Wang, Shujiang; Tavakoli, Shima; Parvathaneni, Ro ...; Nawale, Ganesh N ...; Oommen, Oommen P ...; Hilborn, Jöns, 1 ...; show more...; Varghese, Oommen ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Polymer Chemistr ...

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