Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother-Child Study (NewGeneris)

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Fältnamn	Indikatorer	Metadata
000		04764naa a2200673 4500
001		oai:DiVA.org:su-87122
003		SwePub
008		130128s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:125869657
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-871222 URI
024	7	a https://doi.org/10.1289/ehp.12053272 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1258696572 URI
040		a (SwePub)sud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Pedersen, Marie4 aut
245	1 0	a Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet :b The European Prospective Mother-Child Study (NewGeneris)
264	1	b Environmental Health Perspectives,c 2012
338		a print2 rdacarrier
500		a AuthorCount:24;
520		a BACKGROUND: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. OBJECTIVES: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother child study. METHODS: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. RESULTS: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for Factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. CONCLUSIONS: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. IF confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.
650	7	a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe
650	7	a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng
653		a biomarker
653		a children
653		a diet
653		a intrauterine growth restriction
653		a in utero exposure
700	1	a von Stedingk, Hansu Stockholms universitet,Institutionen för material- och miljökemi (MMK)4 aut0 (Swepub:su)hvons
700	1	a Botsivali, Maria4 aut
700	1	a Agramunt, Silvia4 aut
700	1	a Alexander, Jan4 aut
700	1	a Brunborg, Gunnar4 aut
700	1	a Chatzi, Leda4 aut
700	1	a Fleming, Sarah4 aut
700	1	a Fthenou, Eleni4 aut
700	1	a Granum, Berit4 aut
700	1	a Gutzkow, Kristine B.4 aut
700	1	a Hardie, Laura J.4 aut
700	1	a Knudsen, Lisbeth E.4 aut
700	1	a Kyrtopoulos, Soterios A.4 aut
700	1	a Mendez, Michelle A.4 aut
700	1	a Merlo, Domenico F.4 aut
700	1	a Nielsen, Jeanette K.4 aut
700	1	a Rydberg, Peru Stockholms universitet,Institutionen för material- och miljökemi (MMK)4 aut0 (Swepub:su)rydberg
700	1	a Segerback, Danu Karolinska Institutet4 aut
700	1	a Sunyer, Jordi4 aut
700	1	a Wright, John4 aut
700	1	a Törnqvist, Margaretau Stockholms universitet,Institutionen för material- och miljökemi (MMK)4 aut0 (Swepub:su)mt
700	1	a Kleinjans, Jos C.4 aut
700	1	a Kogevinas, Manolis4 aut
710	2	a Stockholms universitetb Institutionen för material- och miljökemi (MMK)4 org
773	0	t Journal of Environmental Health Perspectivesd : Environmental Health Perspectivesg 120:12, s. 1739-1745q 120:12<1739-1745x 0091-6765x 1552-9924
856	4	u https://doi.org/10.1289/ehp.1205327
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87122
856	4 8	u https://doi.org/10.1289/ehp.1205327
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:125869657

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