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  • Norén, Bengt,1955-Linköpings universitet,Medicinsk radiologi,Hälsouniversitetet (author)

Separation of advanced from mild fibrosis in diffuse liver disease using 31P magnetic resonance spectroscopy

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-43125
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43125URI
  • https://doi.org/10.1016/j.ejrad.2007.06.004DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • 31P-MRS using DRESS was used to compare absolute liver metabolite concentrations (PME, Pi, PDE, γATP, αATP, βATP) in two distinct groups of patients with chronic diffuse liver disorders, one group with steatosis (NAFLD) and none to moderate inflammation (n = 13), and one group with severe fibrosis or cirrhosis (n = 16). All patients underwent liver biopsy and extensive biochemical evaluation. A control group (n = 13) was also included. Absolute concentrations and the anabolic charge, AC = {PME}/({PME} + {PDE}), were calculated.Comparing the control and cirrhosis groups, lower concentrations of PDE (p = 0.025) and a higher AC (p < 0.001) were found in the cirrhosis group. Also compared to the NAFLD group, the cirrhosis group had lower concentrations of PDE (p = 0.01) and a higher AC (p = 0.009). No significant differences were found between the control and NAFLD group. When the MRS findings were related to the fibrosis stage obtained at biopsy, there were significant differences in PDE between stage F0–1 and stage F4 and in AC between stage F0–1 and stage F2–3.Using a PDE concentration of 10.5 mM as a cut-off value to discriminate between mild, F0–2, and advanced, F3–4, fibrosis the sensitivity and specificity were 81% and 69%, respectively. An AC cut-off value of 0.27 showed a sensitivity of 93% and a specificity of 54%.In conclusion, the results suggest that PDE is a marker of liver fibrosis, and that AC is a potentially clinically useful parameter in discriminating mild fibrosis from advanced.

Subject headings and genre

  • Absolute quantification; Phosphorus; MRS; Steatosis; In vivo
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dahlqvist Leinhard, Olof,1978-Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Hälsouniversitetet(Swepub:liu)oloda24 (author)
  • Lundberg, Peter,1958-Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping,Radiofysikavdelningen(Swepub:liu)petlu11 (author)
  • Almer, Sven,1953-Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)sveal38 (author)
  • Kechagias, Stergios,1969-Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)steke00 (author)
  • Ekstedt, Mattias,1976-Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)matek92 (author)
  • Franzén, LennartMedilab, Täby, Sweden (author)
  • Wirell, Staffan,1946-Linköpings universitet,Medicinsk radiologi,Hälsouniversitetet(Swepub:liu)stawi86 (author)
  • Smedby, Örjan,1956-Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping(Swepub:liu)orjsm14 (author)
  • Linköpings universitetMedicinsk radiologi (creator_code:org_t)

Related titles

  • In:European Journal of Radiology: Elsevier66:2, s. 313-3200720-048X1872-7727

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