WFRF:(Olsen Jessica M.)
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Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation
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- Olsen, Jessica M. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Sato, Masaaki (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Monash Institute of Pharmaceutical Sciences, Australia
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- Dallner, Olof S. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,The Rockefeller University, USA
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- Pisani, Didier F. (author)
- Jean-Claude, Chambard (author)
- Amri, Ez-Zoubir (author)
- Hutchinson, Dana S. (author)
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- (creator_code:org_t)
- 2014-11-10
- 2014
- English.
- In: Journal of Cell Biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 207:3
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in β3-adrenoceptor-stimulated glucose uptake in brown adipose tissue. We show that β3-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is comprised of two different parts: one part dependent on cAMP-mediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on mTOR complex 2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane, leading to increased glucose uptake. Both parts are essential for β3-adrenoceptor-stimulated glucose uptake. Importantly, the effect of β3-adrenoceptor on mTOR complex 2 is independent of the classical insulin-phosphoinositide 3-kinase-Akt pathway, highlighting a novel mechanism of mTOR complex 2 activation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- fysiologi
- Physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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