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Sökning: WFRF:(Smeets F.) > (2015-2019) > Ciliary neurotrophi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003493naa a2200445 4500
001oai:lup.lub.lu.se:17f5f8c8-f7d4-4ba2-87fb-54979e867749
003SwePub
008160401s2015 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/81487562 URI
0247 a https://doi.org/10.1038/srep155292 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Askmyr, Mariau Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-mj0
2451 0a Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.
264 c 2015-10-21
264 1b Springer Science and Business Media LLC,c 2015
338 a electronic2 rdacarrier
520 a The gp130 receptor and its binding partners play a central role in cytokine signalling. Ciliary neurotrophic factor (CNTF) is one of the cytokines that signals through the gp130 receptor complex. CNTF has previously been shown to be a negative regulator of trabecular bone remodelling and important for motor neuron development. Since haematopoietic cell maintenance and differentiation is dependent on the bone marrow (BM) microenvironment, where cells of the osteoblastic lineage are important regulators, we hypothesised that CNTF may also have important roles in regulating haematopoiesis. Analysis of haematopoietic parameters in male and female Cntf(-/-) mice at 12 and 24 weeks of age revealed altered B lymphopoiesis. Strikingly, the B lymphocyte phenotype differed based on sex, age and also the BM microenvironment in which the B cells develop. When BM cells from wildtype mice were transplanted into Cntf(-/-) mice, there were minimal effects on B lymphopoiesis or bone parameters. However, when Cntf(-/-) BM cells were transplanted into a wildtype BM microenvironment, there were changes in both haematopoiesis and bone parameters. Our data reveal that haematopoietic cell-derived CNTF has roles in regulating BM B cell lymphopoiesis and both trabecular and cortical bone, the latter in a sex-dependent manner.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a White, Kirby E4 aut
7001 a Jovic, Tanja4 aut
7001 a King, Hannah A4 aut
7001 a Quach, Julie M4 aut
7001 a Maluenda, Ana C4 aut
7001 a Baker, Emma K4 aut
7001 a Smeets, Monique F4 aut
7001 a Walkley, Carl R4 aut
7001 a Purton, Louise E4 aut
7102 a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 5q 5x 2045-2322
8564 u https://portal.research.lu.se/files/4307518/8839568x primaryx freey FULLTEXT
8564 u http://www.ncbi.nlm.nih.gov/pubmed/26487326?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1038/srep15529x freey FULLTEXT
8564 u https://www.nature.com/articles/srep15529.pdf
8564 8u https://lup.lub.lu.se/record/8148756
8564 8u https://doi.org/10.1038/srep15529

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