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Usefulness of a cli...
Usefulness of a clinical risk score to predict the response to cardiac resynchronization therapy
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- Providencia, Rui (author)
- Barts Health NHS Trust,University College London,Nouvelles Cliniques Nantaises
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- Marijon, Eloi (author)
- Paris Descartes University,Hôpital Européen Georges-Pompidou
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- Barra, Sergio (author)
- Papworth Hospital
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- Reitan, Christian (author)
- Lund University,Lunds universitet,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Breitenstein, Alexander (author)
- University Hospital of Zurich
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- Defaye, Pascal (author)
- Grenoble University Hospital
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- Papageorgiou, Nikolaos (author)
- Barts Health NHS Trust
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- Duehmke, Rudolph (author)
- Papworth Hospital
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- Winnik, Stephan (author)
- University Hospital of Zurich
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- Ang, Richard (author)
- Barts Health NHS Trust
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- Klug, Didier (author)
- Lille University Hospital
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- Gras, Daniel (author)
- Nouvelles Cliniques Nantaises
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- Oezkartal, Tardu (author)
- University Hospital of Zurich
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- Segal, Oliver R. (author)
- Barts Health NHS Trust
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- Deharo, Jean Claude (author)
- La Timone University Hospital
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- Leclercq, Christophe (author)
- Rennes University Hospital
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- Lambiase, Pier D. (author)
- Barts Health NHS Trust
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- Fauchier, Laurent (author)
- University Hospital of Tours
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- Bordachar, Pierre (author)
- Hopital Haut-Leveque C.H.U de Bordeaux
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- Steffel, Jan (author)
- University Hospital of Zurich
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- Sadoul, Nicolas (author)
- University Hospital of Nancy
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- Piot, Olivier (author)
- Centre Cardiologique du Nord, Saint Denis
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- Borgquist, Rasmus (author)
- University Hospital of Zurich
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- Agarwal, Sharad (author)
- Papworth Hospital
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- Chow, Anthony (author)
- Barts Health NHS Trust
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- Boveda, Serge (author)
- Clinique Pasteur, Toulouse
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(creator_code:org_t)
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- Elsevier BV, 2018
- 2018
- English 6 s.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 260, s. 82-87
- Related links:
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http://dx.doi.org/10...
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https://discovery.uc...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Almost 1/3 of heart failure patients fail to respond to cardiac resynchronization therapy (CRT). A simple clinical score to predict who these patients are at the moment of referral or at time of implant may be of importance for early optimization of their management. Methods: Observational study. A risk score was derived from factors associated to CRT response. The derivation cohort was composed of 1301 patients implanted with a CRT defibrillator in a multi-center French cohort-study. External validation of this score and assessment of its association with CRT response and all-cause mortality and/or heart transplant was performed in 1959 CRT patients implanted in 4 high-volume European centers. Results: Independent predictors of CRT response in the derivation cohort were: female gender (OR = 2.08, 95% CI 1.26–3.45), NYHA class ≤ III (OR = 2.71, 95% CI 1.63–4.52), left ventricular ejection fraction ≥ 25% (OR = 1.75, 95% CI 1.27–2.41), QRS duration ≥ 150 ms (OR = 1.70, 95% CI 1.25–2.30) and estimated glomerular filtration rate ≥ 60 mL/min (OR = 2.01, 95% CI 1.48–2.72). Each was assigned 1 point. External validation showed good calibration (Hosmer–Lemeshow test-P = 0.95), accuracy (Brier score = 0.19) and discrimination (c-statistic = 0.67), with CRT response increasing progressively from 37.5% in patients with a score of 0 to 91.9% among those with score of 5 (Gamma for trend = 0.44, P < 0.001). Similar results were observed regarding all-cause mortality or heart transplant. Conclusion: The ScREEN score (Sex category, Renal function, ECG/QRS width, Ejection fraction and NYHA class) is composed of widely validated, easy to obtain predictors of CRT response, and predicts CRT response and overall mortality. It should be helpful in facilitating early consideration of alternative therapies for predicted non-responders to CRT therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- DAI-PP
- Heart failure
- Mortality
- Responders
- Risk stratification
- Score
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Providencia, Rui
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Marijon, Eloi
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Barra, Sergio
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Reitan, Christia ...
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Breitenstein, Al ...
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Defaye, Pascal
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Papageorgiou, Ni ...
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Duehmke, Rudolph
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Winnik, Stephan
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Ang, Richard
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Klug, Didier
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Gras, Daniel
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Oezkartal, Tardu
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Segal, Oliver R.
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Deharo, Jean Cla ...
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Leclercq, Christ ...
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Lambiase, Pier D ...
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Fauchier, Lauren ...
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Bordachar, Pierr ...
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Steffel, Jan
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Sadoul, Nicolas
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Piot, Olivier
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Borgquist, Rasmu ...
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Agarwal, Sharad
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Chow, Anthony
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Boveda, Serge
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Lund University