Search: WFRF:(Thomas Julie A.) > (2015-2019) > Ovarian cancer risk...
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001 | oai:DiVA.org:uu-419027 | |
003 | SwePub | |
008 | 200908s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-159048 | |
009 | oai:prod.swepub.kib.ki.se:140827619 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4190272 URI |
024 | 7 | a https://doi.org/10.1002/ijc.320752 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1590482 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1408276192 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fortner, Renée T.4 aut |
245 | 1 0 | a Ovarian cancer risk factors by tumor aggressiveness :b An analysis from the Ovarian Cancer Cohort Consortium |
264 | c 2019-01-14 | |
264 | 1 | b Wiley,c 2019 |
338 | a print2 rdacarrier | |
520 | a Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a aggressiveness | |
653 | a ovarian cancer | |
653 | a prospective cohort | |
653 | a risk factors | |
653 | a subtypes | |
700 | 1 | a Poole, Elizabeth M.4 aut |
700 | 1 | a Wentzensen, Nicolas A.4 aut |
700 | 1 | a Trabert, Britton4 aut |
700 | 1 | a White, Emily4 aut |
700 | 1 | a Arslan, Alan A.4 aut |
700 | 1 | a Patel, Alpa V.4 aut |
700 | 1 | a Setiawan, V. Wendy4 aut |
700 | 1 | a Visvanathan, Kala4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Adami, Hans-Olovu Karolinska Institutet4 aut |
700 | 1 | a Black, Amanda4 aut |
700 | 1 | a Bernstein, Leslie4 aut |
700 | 1 | a Brinton, Louise A.4 aut |
700 | 1 | a Buring, Julie4 aut |
700 | 1 | a Clendenen, Tess V.4 aut |
700 | 1 | a Fournier, Agnès4 aut |
700 | 1 | a Fraser, Gary4 aut |
700 | 1 | a Gapstur, Susan M.4 aut |
700 | 1 | a Gaudet, Mia M.4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Gram, Inger T.4 aut |
700 | 1 | a Hartge, Patricia4 aut |
700 | 1 | a Hoffman-Bolton, Judith4 aut |
700 | 1 | a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002 |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Kirsh, Victoria A.4 aut |
700 | 1 | a Knutsen, Synnove4 aut |
700 | 1 | a Koh, Woon-Puay4 aut |
700 | 1 | a Lacey, James V.4 aut |
700 | 1 | a Lee, I-Min4 aut |
700 | 1 | a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001 |
700 | 1 | a Merritt, Melissa A.4 aut |
700 | 1 | a Milne, Roger L.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Peters, Ulrike4 aut |
700 | 1 | a Poynter, Jenny N.4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Robien, Kim4 aut |
700 | 1 | a Rohan, Thomas4 aut |
700 | 1 | a Sánchez, Maria-José4 aut |
700 | 1 | a Schairer, Catherine4 aut |
700 | 1 | a Schouten, Leo J.4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Townsend, Mary K.4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a van den Brandt, Piet A.4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Wilkens, Lynne4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet4 aut |
700 | 1 | a Yang, Hannah P.4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a Tworoger, Shelley S.4 aut |
710 | 2 | a Karolinska Institutetb Obstetrik och gynekologi4 org |
773 | 0 | t International Journal of Cancerd : Wileyg 145:1, s. 58-69q 145:1<58-69x 0020-7136x 1097-0215 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32075 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419027 |
856 | 4 8 | u https://doi.org/10.1002/ijc.32075 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-159048 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140827619 |
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