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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005511naa a2200589 4500
001oai:DiVA.org:oru-107635
003SwePub
008230816s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-453772
009oai:slubar.slu.se:113158
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1076352 URI
0247 a https://doi.org/10.1186/s12866-021-02260-92 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4537722 URI
0247 a https://res.slu.se/id/publ/1131582 URI
040 a (SwePub)orud (SwePub)uud (SwePub)slu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dube, Faruku Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,National Veterinary Institute (SVA)4 aut
2451 0a Benzylpenicillin-producing Trichophyton erinacei and methicillin resistant Staphylococcus aureus carrying the mecC gene on European hedgehogs :b a pilot-study
264 c 2021-07-15
264 1b BioMed Central (BMC),c 2021
338 a print2 rdacarrier
500 a The study was funded by The Royal Swedish Academy of Agriculture and Forestry (GFS2018-0069) and was co-financed by the National Veterinary Institute (SVA), Uppsala, Sweden.
520 a BACKGROUND: A high carriage rate of methicillin-resistant Staphylococcus aureus with the mecC gene (mecC-MRSA) has been described among Wild European hedgehogs (Europeaus erineaus). Due to this frequent occurrence, it has been suggested that hedgehogs could be a natural reservoir for mecC-MRSA. However, the reason why hedgehogs carry mecC-MRSA remains unknown, but it has been hypothesized that mecC-MRSA could have evolved on the skin of hedgehogs due to the co-occurrence with antibiotic producing dermatophytes. The aim of this pilot-study was therefore to investigate if hedgehogs in Sweden carry Trichophyton spp. and to provide evidence that these dermatophytes are able to produce penicillin or similar substances. In addition, the study aimed to identify if dermatophytes co-occurred with mecC-MRSA.METHODS: Samples were collected from hedgehogs (Europeaus erineaus) that were euthanized or died of natural causes. All samples were screened for dermatophytes and mecC-MRSA using selective cultivation methods. Suspected isolates were characterized using PCR-based methods, genome sequencing and bioinformatic analyses. Identification of penicillin was performed by ultra-high-performance liquid chromatography-tandem mass spectrometry.RESULTS: In total 23 hedgehogs were investigated, and it was shown that two carried Trichophyton erinacei producing benzyl-penicillin, and that these hedgehogs also carried mecC-MRSA. The study also showed that 60% of the hedgehogs carried mecC-MRSA.CONCLUSION: The pilot-study demonstrated that Trichophyton erinacei, isolated from Swedish hedgehogs, can produce benzylpenicillin and that these benzylpenicillin-producing T. erinacei co-occurred with mecC-MRSA. The study also reconfirmed the high occurrence of mecC-MRSA among hedgehogs.
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653 a Antibiotics
653 a Benzylpenicillin
653 a Dermatophytes
653 a Europeaus erineaus
653 a Hedgehogs
653 a MRSA
653 a Staphylococcus aureus
653 a Trichophyton erinacei
653 a Wildlife
7001 a Söderlund, Robertu Department of Microbiology, National Veterinary Institute, SVA, 75189, Uppsala, Sweden,Natl Vet Inst, Dept Microbiol, SVA, S-75189 Uppsala, Sweden4 aut
7001 a Lampinen Salomonsson, Matildau Uppsala universitet,Institutionen för läkemedelskemi,Natl Vet Inst, Dept Chem Environm & Feed Hyg, SVA, S-75189 Uppsala, Sweden4 aut0 (Swepub:uu)malam254
7001 a Troell, Karinu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Natl Vet Inst, Dept Microbiol, SVA, S-75189 Uppsala, Sweden4 aut0 (Swepub:uu)kartr688
7001 a Börjesson, Stefan,d 1979-u Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), 75189, Uppsala, Sweden; Department of Microbiology, Public Health Agency of Sweden, 17182, Solna, Sweden,Natl Vet Inst SVA, Dept Anim Hlth & Antimicrobial Strategies, S-75189 Uppsala, Sweden; Publ Hlth Agcy Sweden, Dept Microbiol, S-17182 Solna, Sweden4 aut0 (Swepub:oru)sebn
7102 a Sveriges lantbruksuniversitetb Inst för biomedicin och veterinär folkhälsovetenskap4 org
7102 a Sveriges lantbruksuniversitet
7730 t BMC Microbiologyd : BioMed Central (BMC)g 21q 21x 1471-2180
8564 u https://doi.org/10.1186/s12866-021-02260-9y Fulltext
8564 u https://bmcmicrobiol.biomedcentral.com/track/pdf/10.1186/s12866-021-02260-9
8564 u https://uu.diva-portal.org/smash/get/diva2:1602516/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://pub.epsilon.slu.se/id/eprint/25086/contentsx primaryx Raw objectx freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107635
8564 8u https://doi.org/10.1186/s12866-021-02260-9
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453772
8564 8u https://res.slu.se/id/publ/113158

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