Sökning: WFRF:(Van Zuydam N.) > Genome-Wide Associa...
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000 | 11084naa a2200841 4500 | |
001 | oai:DiVA.org:uu-458405 | |
003 | SwePub | |
008 | 211110s2021 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:e1caed53-8988-4aec-bc62-cd3abd2a9d95 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4584052 URI |
024 | 7 | a https://doi.org/10.1161/CIRCGEN.119.0028622 DOI |
024 | 7 | a https://lup.lub.lu.se/record/e1caed53-8988-4aec-bc62-cd3abd2a9d952 URI |
040 | a (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van Zuydam, Natalieu Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.,University of Oxford4 aut |
245 | 1 0 | a Genome-Wide Association Study of Peripheral Artery Disease |
264 | 1 | b Lippincott Williams & Wilkins,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and smoking status. Methods: We identified genetic variants associated with PAD and then meta-analyzed with published summary statistics from the Million Veterans Program and UK Biobank to replicate their findings. Next, we ran stratified genome-wide association analysis in ever smokers, never smokers, individuals with diabetes, and individuals with no history of diabetes and corresponding interaction analyses, to identify variants that modify the risk of PAD by diabetic or smoking status. Results: We identified 5 genome-wide significant (P-association <= 5x10(-8)) associations with PAD in 449 548 (N-cases=12 086) individuals of European ancestry near LPA (lipoprotein [a]), CDKN2BAS1 (CDKN2B antisense RNA 1), SH2B3 (SH2B adaptor protein 3) - PTPN11 (protein tyrosine phosphatase non-receptor type 11), HDAC9 (histone deacetylase 9), and CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) loci (which overlapped previously reported associations). Meta-analysis with variants previously associated with PAD showed that 18 of 19 published variants remained genome-wide significant. In individuals with diabetes, rs116405693 at the CCSER1 (coiled-coil serine rich protein 1) locus was associated with PAD (odds ratio [95% CI], 1.51 [1.32-1.74], P-diabetes=2.5x10(-9), P-interactionwithdiabetes=5.3x10(-7)). Furthermore, in smokers, rs12910984 at the CHRNA3 locus was associated with PAD (odds ratio [95% CI], 1.15 [1.11-1.19], P-smokers=9.3x10(-10), P-interactionwithsmoking=3.9x10(-5)). Conclusions: Our analyses confirm the published genetic associations with PAD and identify novel variants that may influence susceptibility to PAD in the context of diabetes or smoking status. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a diabetes | |
653 | a genome-wide association study | |
653 | a peripheral vascular disease | |
653 | a smoking | |
653 | a diabetes | |
653 | a genome-wide association study | |
653 | a peripheral vascular disease | |
653 | a smoking | |
700 | 1 | a Stiby, Alexanderu Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit, Oxford, England.,University of Oxford4 aut |
700 | 1 | a Abdalla, Moustafau Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.,University of Oxford4 aut |
700 | 1 | a Austin, Erinu Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.;Mayo Clin, Gonda Vasc Ctr, 200 First St SW, Rochester, MN 55905 USA.,Mayo Clinic Minnesota4 aut |
700 | 1 | a Dahlstrom, Emma H.u Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.;Univ Helsinki, Abdominal Ctr, Nephrol, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland.,Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital4 aut |
700 | 1 | a McLachlan, Stelau Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.,University of Edinburgh4 aut |
700 | 1 | a Vlachopoulou, Efthymiau Univ Helsinki, Dept Med, Helsinki Univ Cent Hosp, Helsinki, Finland.,University of Helsinki4 aut |
700 | 1 | a Ahlqvist, Emmau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah |
700 | 1 | a Di Liao, Chenu Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.;SickKids, Genet & Genome Biol, Toronto, ON, Canada.,University of Toronto4 aut |
700 | 1 | a Sandholm, Niinau Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.;Univ Helsinki, Abdominal Ctr, Nephrol, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland.,Helsinki University Central Hospital,Folkhälsan Research Center,University of Helsinki4 aut |
700 | 1 | a Forsblom, Carolu Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.;Univ Helsinki, Abdominal Ctr, Nephrol, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland.,Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital4 aut |
700 | 1 | a Mahajan, Anubhau Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Genentech Inc, San Francisco, CA USA.,University of Oxford4 aut |
700 | 1 | a Robertson, Neil R.u Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.,University of Oxford4 aut |
700 | 1 | a Rayner, N. Williamu Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, Cambs, England.,University of Oxford4 aut |
700 | 1 | a Lindholm, Eerou Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-eli |
700 | 1 | a Sinisalo, Juhau Univ Helsinki, Heart & Lung Ctr, Helsinki, Finland.,University of Helsinki4 aut |
700 | 1 | a Perola, Markusu Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Finnish Inst Hlth & Welf, Helsinki, Finland.,University of Helsinki4 aut0 (Swepub:lu)med-mkp |
700 | 1 | a Kallio, Millau Univ Helsinki, Vasc Surg, Abdominal Ctr, Helsinki, Finland.,University of Helsinki4 aut |
700 | 1 | a Weiss, Emilyu Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.,University of Edinburgh4 aut |
700 | 1 | a Price, Jackieu Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.,University of Edinburgh4 aut |
700 | 1 | a Paterson, Andrewu Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.;SickKids, Genet & Genome Biol, Toronto, ON, Canada.,University of Toronto,University of Manchester,University of Liverpool4 aut |
700 | 1 | a Klein, Barbarau Univ Wisconsin Madison, Ocular Epidemiol Res Grp, Madison, WI USA.,University of Wisconsin-Madison4 aut |
700 | 1 | a Salomaa, Veikkou Finnish Inst Hlth & Welf, Helsinki, Finland.4 aut |
700 | 1 | a Palmer, Colin N. A.u Univ Dundee, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Ninewells Hosp & Med Sch, Dundee, Scotland.,University of Dundee4 aut |
700 | 1 | a Groop, Per-Henriku Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.;Univ Helsinki, Abdominal Ctr, Nephrol, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland.;Monash Univ, Dept Med, Cent Clin Sch, Melbourne, Vic, Australia.,Helsinki University Central Hospital,University of Helsinki,Folkhälsan Research Center4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a McCarthy, Mark I.u Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Oxford Univ Hosp Trust, Oxford NIHR Biomed Res Ctr, Oxford, England.;Genentech Inc, San Francisco, CA USA.,University of Oxford,Oxford University Hospitals NHS Foundation Trust4 aut |
700 | 1 | a de Andrade, Marizau Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.;Mayo Clin, Gonda Vasc Ctr, 200 First St SW, Rochester, MN 55905 USA.,Mayo Clinic Minnesota4 aut |
700 | 1 | a Morris, Andrew P.u Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Manchester, Lancs, England.4 aut |
700 | 1 | a Hopewell, Jemma C.u Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit, Oxford, England.,University of Oxford4 aut |
700 | 1 | a Colhoun, Helen M.u Univ Edinburgh, Inst Genet & Mol Med, Western Gen Hosp Campus, Edinburgh, Midlothian, Scotland.,University of Edinburgh4 aut |
700 | 1 | a Kullo, Iftikhar J.u Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.;Mayo Clin, Gonda Vasc Ctr, 200 First St SW, Rochester, MN 55905 USA.,Mayo Clinic Minnesota4 aut |
710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
773 | 0 | t Circulationd : Lippincott Williams & Wilkinsg 14:5q 14:5x 2574-8300 |
856 | 4 | u https://doi.org/10.1161/CIRCGEN.119.002862y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1610323/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1161/CIRCGEN.119.002862x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458405 |
856 | 4 8 | u https://doi.org/10.1161/CIRCGEN.119.002862 |
856 | 4 8 | u https://lup.lub.lu.se/record/e1caed53-8988-4aec-bc62-cd3abd2a9d95 |
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