Deciphering the 8q24.21 association for glioma

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Fältnamn	Indikatorer	Metadata
000		04376naa a2200745 4500
001		oai:lup.lub.lu.se:75e8f7e5-e8f9-48e9-83aa-ba1a139de0ec
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/39314432 URI
024	7	a https://doi.org/10.1093/hmg/ddt0632 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Enciso-Mora, Victor4 aut
245	1 0	a Deciphering the 8q24.21 association for glioma
264		c 2013-02-11
264	1	b Oxford University Press (OUP),c 2013
520		a We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequencing data generated on 253 individuals. Analysis revealed an imputed low-frequency SNP rs55705857 (P = 2.24 x 10(-38)) which was sufficient to fully capture the 8q24.21 association. Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 x 10(-67)). Validation of the non-GBM association was shown in three additional datasets (625 non-GBM cases, 2412 controls; P = 1.41 x 10(-28)). In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 x 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. These data provide additional insights into the aetiological basis of glioma development.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Hosking, Fay J.4 aut
700	1	a Kinnersley, Ben4 aut
700	1	a Wang, Yufei4 aut
700	1	a Shete, Sanjay4 aut
700	1	a Zelenika, Diana4 aut
700	1	a Broderick, Peter4 aut
700	1	a Idbaih, Ahmed4 aut
700	1	a Delattre, Jean-Yves4 aut
700	1	a Hoang-Xuan, Khe4 aut
700	1	a Marie, Yannick4 aut
700	1	a Di Stefano, Anna Luisa4 aut
700	1	a Labussiere, Marianne4 aut
700	1	a Dobbins, Sara4 aut
700	1	a Boisselier, Blandine4 aut
700	1	a Ciccarino, Pietro4 aut
700	1	a Rossetto, Marta4 aut
700	1	a Armstrong, Georgina4 aut
700	1	a Liu, Yanhong4 aut
700	1	a Gousias, Konstantinos4 aut
700	1	a Schramm, Johannes4 aut
700	1	a Lau, Ching4 aut
700	1	a Hepworth, Sarah J.4 aut
700	1	a Strauch, Konstantin4 aut
700	1	a Mueller-Nurasyid, Martina4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Franke, Andre4 aut
700	1	a Moebus, Susanne4 aut
700	1	a Eisele, Lewin4 aut
700	1	a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-asf
700	1	a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-khk
700	1	a Tomlinson, Ian P.4 aut
700	1	a Swerdlow, Anthony4 aut
700	1	a Lathrop, Mark4 aut
700	1	a Simon, Matthias4 aut
700	1	a Bondy, Melissa4 aut
700	1	a Sanson, Marc4 aut
700	1	a Houlston, Richard S.4 aut
710	2	a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 22:11, s. 2293-2302q 22:11<2293-2302x 0964-6906x 1460-2083
856	4	u http://dx.doi.org/10.1093/hmg/ddt063y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3652416?pdf=render
856	4 8	u https://lup.lub.lu.se/record/3931443
856	4 8	u https://doi.org/10.1093/hmg/ddt063

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