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Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases.
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- Kovács, Anikó, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
- Schmidt, Emese (author)
- Bégány, Agnes (author)
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- Hunyadi, János (author)
- Szegedi, Andrea (author)
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- (creator_code:org_t)
- Medical Journals Sweden AB, 2004
- 2004
- English.
- In: Acta dermato-venereologica. - : Medical Journals Sweden AB. - 0001-5555. ; 84:2, s. 116-9
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cellular connection between normal cells. P-cadherin is involved in the selective adhesion of epidermal cells, and is expressed only on the surfaces of the two basal layers. We examined the expression of P-cadherin in some autoimmune bullous skin diseases and Darier's disease using immunohistochemistry and found P-cadherin to be strongly upregulated. We believe the upregulation is compensatory to the primary pathophysiological events in the various bullous dermatoses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Acantholysis
- immunology
- pathology
- Biomarkers
- analysis
- Biopsy
- Needle
- Cadherins
- analysis
- metabolism
- Darier Disease
- immunology
- pathology
- Female
- Humans
- Immunohistochemistry
- Male
- Microscopy
- Immunoelectron
- Pemphigoid
- Bullous
- immunology
- pathology
- Pemphigus
- immunology
- pathology
- Reference Values
- Sampling Studies
- Sensitivity and Specificity
- Severity of Illness Index
- Skin Diseases
- Vesiculobullous
- immunology
- pathology
- Up-Regulation
Publication and Content Type
- ref (subject category)
- art (subject category)
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