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High sequence varia...
High sequence variability among hemocyte-specific Kazal-type proteinase inhibitors in decapod crustaceans
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- Cerenius, Lage, 1956- (författare)
- Uppsala universitet,Jämförande fysiologi,Institutionen för organismbiologi
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- Haipeng, Liu (författare)
- State Key Laboratory of Marine Environmental Science, College of Oceanography and Environmental Science, Xiamen University, Xiamen, 361005 Fujian, China
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- Zhang, Yanjiao (författare)
- Uppsala universitet,Jämförande fysiologi
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- Rimphanitchayakit, Vichien (författare)
- Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
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- Tassanakajon, Anchalee (författare)
- Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
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- Andersson, M. Gunnar (författare)
- Uppsala universitet,Centrum för bioinformatik
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- Söderhäll, Kenneth (författare)
- Uppsala universitet,Jämförande fysiologi,Institutionen för organismbiologi
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- Söderhäll, Irene (författare)
- Uppsala universitet,Jämförande fysiologi,Institutionen för organismbiologi
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(creator_code:org_t)
- Elsevier, 2010
- 2010
- Engelska.
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Ingår i: Developmental and Comparative Immunology. - : Elsevier. - 0145-305X .- 1879-0089. ; 34:1, s. 69-75
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Crustacean hemocytes were found to produce a large number of transcripts coding for Kazal-type proteinase inhibitors (KPIs). A detailed study performed with the crayfish Pacifastacus leniusculus and the shrimp Penaeus monodon revealed the presence of at least 26 and 20 different Kazal domains from the hemocyte KPIs, respectively. Comparisons with KPIs from other taxa indicate that the sequences of these domains evolve rapidly. A few conserved positions, e.g. six invariant cysteines were present in all domain sequences whereas the position of P1 amino acid, a determinant for substrate specificity, varied highly. A study with a single crayfish animal suggested that even at the individual level considerable sequence variability among hemocyte KPIs produced exist. Expression analysis of four crayfish KPI transcripts in hematopoietic tissue cells and different hemocyte types suggest that some of these KPIs are likely to be involved in hematopoiesis or hemocyte release as they were produced in particular hemocyte types or maturation stages only.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Innate immunity
- Host–parasite interactions
- Hematopoiesis
- Crayfish
- Shrimp
- Kazal inhibitor
- Serine proteinase inhibitor
- WSSV
- Biology
- Biologi
- Immunologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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