SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Abrahamsson M)
 

Sökning: WFRF:(Abrahamsson M) > Value of flow cytom...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008380naa a2200793 4500
001oai:gup.ub.gu.se/299424
003SwePub
008240528s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-178333
009oai:lup.lub.lu.se:7bab7e42-4df7-4f74-8d4f-140962a25921
009oai:DiVA.org:uu-454517
0247 a https://gup.ub.gu.se/publication/2994242 URI
0247 a https://doi.org/10.1038/s41375-020-01100-52 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1783332 URI
0247 a https://lup.lub.lu.se/record/7bab7e42-4df7-4f74-8d4f-140962a259212 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4545172 URI
040 a (SwePub)gud (SwePub)umud (SwePub)lud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Modvig, Su Copenhagen University Hospital,Vilnius University,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Vilnius Univ Hosp, Santaros Klin, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania.4 aut
2451 0a Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting.
264 c 2020-12-14
264 1b Springer Science and Business Media LLC,c 2021
520 a PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO ALL2008 protocol. When no informative FCM-marker was available, risk stratification was based on real-time quantitative PCR. An informative FCM-marker was found in 96.2% and only two patients (0.14%) had non-informative FCM and non-informative PCR-markers. The overall 5-year event-free survival was 86.1% with a cumulative incidence of relapse (CIR5y) of 9.5%. FCM-MRD levels on days 15 (HzR 4.0, p<0.0001), 29 (HzR 2.7, p<0.0001), and 79 (HzR 3.5, p<0.0001) associated with hazard of relapse adjusted for age, cytogenetics, and WBC. The early (day 15) response associated with CIR5y adjusted for day 29 FCM-MRD, with higher levels in adults (median 2.4×10-2 versus 5.2×10-3, p<0.0001). Undetectable FCM- and/or PCR-MRD on day 29 identified patients with a very good outcome (CIR5y=3.2%). For patients who did not undergo transplantation, day 79 FCM-MRD>10-4 associated with a CIR5y=22.1%. In conclusion, FCM-MRD performed in a multicenter setting is a clinically useful method for MRD-based treatment stratification in BCP-ALL.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Hallböök, Heleneu Uppsala universitet,Uppsala University,Copenhagen University Hospital,Oslo university hospital,Hematologi,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Oslo Univ Hosp, Dept Pathol, Lab Mol Pathol, Oslo, Norway.4 aut0 (Swepub:uu)helehall
7001 a Madsen, H Ou Umeå University,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.4 aut
7001 a Siitonen, Su University of Helsinki,University of Copenhagen,Univ Helsinki, Clin Chem, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.,Univ Copenhagen, Sect Biostat, Copenhagen, Denmark.4 aut
7001 a Rosthøj, S4 aut
7001 a Tierens, Au University of Toronto,Oslo university hospital,Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.;Univ Hosp Oslo, Dept Pathol, Oslo, Norway.4 aut
7001 a Juvonen, Vu University of Turku,Univ Turku, Dept Clin Chem, Turku, Finland.;Univ Turku, Lab Div, Turku, Finland.;Turku Univ Hosp, Turku, Finland.4 aut
7001 a Osnes, L T Nu Oslo university hospital,Herlev Hospital,Oslo Univ Hosp, Dept Immunol, Oslo, Norway.,Herlev Univ Hosp, Dept Hematol, Herlev, Denmark.4 aut
7001 a Vålerhaugen, H4 aut
7001 a Hultdin, Magnusu Umeå universitet,Patologi4 aut0 (Swepub:umu)magn0001
7001 a Matuzeviciene, Ru Vilnius University,Vilnius Univ, Inst Biomed Sci, Fac Med, Dept Physiol Biochem Microbiol & Lab Med, Vilnius, Lithuania.;Vilnius Univ Hosp, Santaros Klin, Ctr Lab Med, Vilnius, Lithuania.4 aut
7001 a Stoskus, M4 aut
7001 a Ehinger, M.u Lund University,Lunds universitet,Uppsala University,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Clin Genet & Pathol, Lund, Sweden.;Lund Univ, Dept Clin Sci Oncol & Pathol, Lund, Sweden.4 aut0 (Swepub:lu)efor-meh
7001 a Lilleorg, Au North Estonia Medical Centre,North Estonia Med Ctr, Dept Clin Immunol, Tallinn, Estonia.4 aut
7001 a Ehinger, M4 aut
7001 a Norén-Nyström, Ulrikau Umeå University,Umeå universitet,Pediatrik,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.4 aut0 (Swepub:umu)kagr0007
7001 a Toft, N4 aut
7001 a Taskinen, Mu Helsinki University Central Hospital,Helsinki Univ Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.4 aut
7001 a Jónsson, O Gu National University Hospital of Iceland,Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.4 aut
7001 a Pruunsild, Ku Tallinn Children's Hospital,Tallinn Childrens Hosp, Tallinn, Estonia.4 aut
7001 a Vaitkeviciene, Gu Vilnius University,Vilnius Univ Hosp, Santariskiu Klin, Childrens Hosp, Vilnius, Lithuania.4 aut
7001 a Vettenranta, Ku University of Helsinki,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Childrens Hosp, Helsinki, Finland.4 aut
7001 a Lund, Bu St. Olav’s University Hospital,St Olavs Univ Hosp, Dept Pediat, Trondheim, Norway.;NTNU, Dept Clin & Mol Med, Trondheim, Norway.4 aut
7001 a Abrahamsson, Jonas,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.4 aut0 (Swepub:gu)xabrjo
7001 a Porwit, A.u Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Fac Med, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.4 aut0 (Swepub:lu)an6742po
7001 a Schmiegelow, Ku Copenhagen University Hospital,Copenhagen Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Fac Med, Copenhagen, Denmark.4 aut
7001 a Marquart, H V4 aut
7001 a Marincevic, Millaray,d 1983-u Uppsala universitet,Klinisk och experimentell patologi4 aut0 (Swepub:uu)milma629
7102 a Copenhagen University Hospitalb Vilnius University4 org
7730 t Leukemiad : Springer Science and Business Media LLCg 35, s. 1894-1906q 35<1894-1906x 1476-5551x 0887-6924
8564 u https://www.nature.com/articles/s41375-020-01100-5.pdf
8564 u https://doi.org/10.1038/s41375-020-01100-5y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1516830/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1038/s41375-020-01100-5x freey FULLTEXT
8564 u https://uu.diva-portal.org/smash/get/diva2:1598564/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/299424
8564 8u https://doi.org/10.1038/s41375-020-01100-5
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178333
8564 8u https://lup.lub.lu.se/record/7bab7e42-4df7-4f74-8d4f-140962a25921
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454517

Hitta via bibliotek

  • Leukemia (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy