Pathophysiology of coronary blood flow in congenital heart disease.

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Fältnamn	Indikatorer	Metadata
000		03594naa a2200337 4500
001		oai:lup.lub.lu.se:8865b591-e0d8-4e62-9437-b657579a0cc1
003		SwePub
008		160404s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/16257652 URI
024	7	a https://doi.org/10.1016/j.ijcard.2010.05.0482 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Aburawi, Elhadiu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-eab
245	1 0	a Pathophysiology of coronary blood flow in congenital heart disease.
264	1	b Elsevier BV,c 2011
338		a electronic2 rdacarrier
520		a OBJECTIVES: The aim was to investigate the effects of volume and pressure overload and increased coronary perfusion pressure on coronary flow (CF) in congenital heart disease (CHD) patients. BACKGROUND: The effects of CHD on CF are poorly mapped. METHODS: A total of 65 patients with acyanotic CHD and 49 age-matched healthy controls were examined by transthoracic Doppler echocardiography. Posterior descending artery flow was measured in patients with pulmonary valve stenosis (PS) and atrial septal defects (ASDs) i.e. in lesions with right ventricular pressure or volume overload, and left anterior descending artery flow in patients with coarctation of the aorta (CoA) and ventricular septal defect (VSD), in lesions with left ventricular pressure or volume overload. The CF data in each patient group were expressed as the percent of the median for healthy controls from the same age group. RESULTS: The CF values were in VSD 172%, ASD 185%, PS 233%, and CoA 773% patients. In CoA patients body surface area (r=0.90, p<0.0001), systolic blood pressure (r=0.72, p<0.0001), diastolic blood pressure (r=0.77, p<0.0001), systolic wall tension (r=-0.77, p=0.004), and signs of inflammation (log CRP, r=-0.75, p=0.007) correlated with CF. CONCLUSIONS: The increase in CF and velocity was most significant in patients with CoA. In newborns, increased coronary perfusion pressure seems to be the most important factor for increased CF, even if the pressure is not assumed to cause a significant increase in flow over the auto-regulatory range of 70-130mmHg. We also showed that inflammation decreases CF.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Pesonen, Erkkiu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-epe
710	2	a Pediatrik, Lundb Sektion V4 org
773	0	t International Journal of Cardiologyd : Elsevier BVg Jul 1, s. 273-277q Jul 1<273-277x 0167-5273
856	4	u https://portal.research.lu.se/files/5161853/1686719.pdfx primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/20573411?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1016/j.ijcard.2010.05.048y FULLTEXT
856	4	u https://lup.lub.lu.se/search/files/5161853/1686719.pdf
856	4 8	u https://lup.lub.lu.se/record/1625765
856	4 8	u https://doi.org/10.1016/j.ijcard.2010.05.048

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Av författaren/redakt...: Aburawi, Elhadi; Pesonen, Erkki

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Lunds universitet

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