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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006040naa a2200529 4500
001oai:DiVA.org:uu-506648
003SwePub
008231010s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5066482 URI
0247 a https://doi.org/10.1186/s12891-023-06509-42 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Grahn, Petrau Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.4 aut
2451 0a Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
264 1b BioMed Central (BMC),c 2023
338 a electronic2 rdacarrier
520 a BackgroundChildhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls.MethodsIn this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5-33.1), 67 survivors (mean age 28.4, range 16.2-43.5) were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, , intervertebral disc protrusions, extrusions, and high-intensity-zone-lesions (HIZ). Groups were also compared for known risk factors of lumbar intervertebral disc (IVD) degeneration.ResultsChildhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p < 0.001). Lumbar disc protrusions at L4-5 (p = 0.02) and extrusions at L3-4 (p = 0.04), L4-5 (p = 0.004), and L5-S1 (p = 0.01) were significantly more common in the BT group compared to the control. The survivor cohort also had significantly more HIZ-lesons than the controls (n=13 and n=1, p=0.003). Age at diagnosis was associated with lower degree of IVD degeneration (p < 0.01). Blood pressure correlated with IVD degeneration (P < 0.05).ConclusionsSigns of early disc degeneration related to tumor treatment can be seen in the IVDs of survivors. Disc degeneration was more severe in children treated in adolescence.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653 a Childhood brain tumor survivor
653 a Radiotherapy
653 a Disc degeneration
7001 a Remes, Tiinau Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut
7001 a Kivisaari, Reettau Univ Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.4 aut
7001 a Suo-Palosaari, Maria. H. H.u Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland.;Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland.4 aut
7001 a Arikoski, Pekka. M. M.u Kuopio Univ Hosp, Kuopio, Finland.4 aut
7001 a Koskenkorva, Paivi K. T.u Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.4 aut
7001 a Lahteenmaki, Paivi M.4 aut
7001 a Lonnqvist, Tuula R. I.u Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut
7001 a Ojaniemi, Marja. K. K.u Univ Oulu, Res Unit Clin Med, Helsinki, Finland.4 aut
7001 a Sirkia, Kirsti H.u Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland.4 aut
7001 a Sutela, Anna. K. K.u Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.4 aut
7001 a Toiviainen-Salo, Sanna-Mariau Univ Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.4 aut
7001 a Rantala, Heikki M. J.u Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.4 aut
7001 a Harila-Saari, Arja H.u Uppsala universitet,Barnonkologisk och neurologisk forskning4 aut0 (Swepub:uu)arjha456
7001 a Niinimaki, Jaakkou Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland.4 aut
7001 a Karppinen, Jarou Oulu Univ Hosp, Oulu, Finland. Finnish Inst Occupat Hlth, Oulu, Finland. Rehabil Serv South Karel Social & Hlth Care Dist, Lappeenranta, Finland.4 aut
7001 a Ahonen, Mattiu Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.4 aut
7102 a Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.b Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 org
7730 t BMC Musculoskeletal Disordersd : BioMed Central (BMC)g 24:1q 24:1x 1471-2474
8564 u https://doi.org/10.1186/s12891-023-06509-4y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1803757/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506648
8564 8u https://doi.org/10.1186/s12891-023-06509-4

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