Sökning: WFRF:(Berge Johan) > Integrated proteoge...
Fältnamn | Indikatorer | Metadata |
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000 | 04069naa a2200481 4500 | |
001 | oai:lup.lub.lu.se:f9fd8851-8510-4ce1-92f4-6486964e5f61 | |
003 | SwePub | |
008 | 210113s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/f9fd8851-8510-4ce1-92f4-6486964e5f612 URI |
024 | 7 | a https://doi.org/10.1136/thoraxjnl-2019-2132002 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Brandsma, Corry Ankeu University Medical Center Groningen4 aut |
245 | 1 0 | a Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1 |
264 | c 2020-01-14 | |
264 | 1 | b BMJ,c 2020 |
300 | a 4 s. | |
520 | a Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a COPD pathology | |
653 | a COPD ÀÜ mechanisms | |
700 | 1 | a Guryev, Victoru University Medical Center Groningen4 aut |
700 | 1 | a Timens, Wimu University Medical Center Groningen4 aut |
700 | 1 | a Ciconelle, Anau University of Groningen4 aut |
700 | 1 | a Postma, DIrkje S.u University Medical Center Groningen4 aut |
700 | 1 | a Bischoff, Raineru University of Groningen4 aut |
700 | 1 | a Johansson, Mariau Lund University4 aut |
700 | 1 | a Ovchinnikova, Ekaterina S.u University Medical Center Groningen4 aut |
700 | 1 | a Malm, Johanu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Department of Translational Medicine,Faculty of Medicine,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)klke-jma |
700 | 1 | a Marko-Varga, Gyorgyu Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)akem-gmv |
700 | 1 | a Fehniger, Thomas E.u Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)elma-tfr |
700 | 1 | a Van Den Berge, Maartenu University Medical Center Groningen4 aut |
700 | 1 | a Horvatovich, Peteru University of Groningen4 aut0 (Swepub:lu)pe4034ho |
710 | 2 | a University Medical Center Groningenb University of Groningen4 org |
773 | 0 | t Thoraxd : BMJg 75:2, s. 180-183q 75:2<180-183x 0040-6376x 1468-3296 |
856 | 4 | u http://dx.doi.org/10.1136/thoraxjnl-2019-213200x freey FULLTEXT |
856 | 4 | u https://thorax.bmj.com/content/thoraxjnl/75/2/180.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/f9fd8851-8510-4ce1-92f4-6486964e5f61 |
856 | 4 8 | u https://doi.org/10.1136/thoraxjnl-2019-213200 |
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