Gap Junctions between Striatal Fast-Spiking Interneurons Regulate Spiking Activity and Synchronization as a Function of Cortical Activity

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Hjorth, JohannesKarolinska Institutet,KTH,Beräkningsbiologi, CB (författare)

Gap Junctions between Striatal Fast-Spiking Interneurons Regulate Spiking Activity and Synchronization as a Function of Cortical Activity

Artikel/kapitelEngelska2009

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2009
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LIBRIS-ID:oai:DiVA.org:kth-14150
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-14150URI
https://doi.org/10.1523/JNEUROSCI.6031-08.2009DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:118620192URI

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Språk:engelska
Sammanfattning på:engelska

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QC 20100720
Striatal fast-spiking (FS) interneurons are interconnected by gap junctions into sparsely connected networks. As demonstrated for cortical FS interneurons, these gap junctions in the striatum may cause synchronized spiking, which would increase the influence that FS neurons have on spiking by the striatal medium spiny (MS) neurons. Dysfunction of the basal ganglia is characterized by changes in synchrony or periodicity, thus gap junctions between FS interneurons may modulate synchrony and thereby influence behavior such as reward learning and motor control. To explore the roles of gap junctions on activity and spike synchronization in a striatal FS population, we built a network model of FS interneurons. Each FS connects to 30-40% of its neighbors, as found experimentally, and each FS interneuron in the network is activated by simulated corticostriatal synaptic inputs. Our simulations show that the proportion of synchronous spikes in FS networks with gap junctions increases with increased conductance of the electrical synapse; however, the synchronization effects are moderate for experimentally estimated conductances. Instead, the main tendency is that the presence of gap junctions reduces the total number of spikes generated in response to synaptic inputs in the network. The reduction in spike firing is due to shunting through the gap junctions; which is minimized or absent when the neurons receive coincident inputs. Together these findings suggest that a population of electrically coupled FS interneurons may function collectively as input detectors that are especially sensitive to synchronized synaptic inputs received from the cortex.

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NATURVETENSKAP Data- och informationsvetenskap Datavetenskap hsv//swe
NATURAL SCIENCES Computer and Information Sciences Computer Sciences hsv//eng
timing-dependent plasticity; electrical synapses; basal ganglia; gabaergic interneurons; spiny neurons; corticostriatal synapses; synaptic plasticity; projection neurons; in-vitro; states
Computer science
Datalogi

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Blackwell, Kim T (författare)
Hellgren Kotaleski, JeanetteKTH,Beräkningsbiologi, CB(Swepub:kth)u13pnwqn (författare)
KTHBeräkningsbiologi, CB (creator_code:org_t)

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Ingår i:Journal of Neuroscience29:16, s. 5276-52860270-64741529-2401

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Av författaren/redakt...: Hjorth, Johannes; Blackwell, Kim T; Hellgren Kotales ...

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NATURVETENSKAP: NATURVETENSKAP; och Data och informa ...; och Datavetenskap

Artiklar i publikationen: Journal of Neuro ...

Av lärosätet: Kungliga Tekniska Högskolan; Karolinska Institutet

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