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Ghrelin decreases s...
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Pietrzak, Michal,1987-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Psykiatriska kliniken i Linköping
(author)
Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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Springer Science+Business Media B.V.2024
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-202021
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202021URI
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https://doi.org/10.1038/s41386-024-01821-6DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [2013-07434]; Marcus and Marianne Wallenberg foundation [2014.0187]; NIH IRP (NIDA); NIH IRP (NIAAA); Linkoeping University
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The stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and survival, but it has been suggested to also be involved in the stress response, in neuropsychiatric conditions, and in alcohol and drug use disorders. Mechanisms related to reward processing might mediate ghrelin's broader effects on complex behaviors, as indicated by animal studies and mostly correlative human studies. Here, using a within-subject double-blind placebo-controlled design with intravenous ghrelin infusion in healthy volunteers (n = 30), we tested whether ghrelin alters sensitivity to reward and punishment in a reward learning task. Parameters were derived from a computational model of participants' task behavior. The reversal learning task with monetary rewards was performed during functional brain imaging to investigate ghrelin effects on brain signals related to reward prediction errors. Compared to placebo, ghrelin decreased punishment sensitivity (t = -2.448, p = 0.021), while reward sensitivity was unaltered (t = 0.8, p = 0.43). We furthermore found increased prediction-error related activity in the dorsal striatum during ghrelin administration (region of interest analysis: t-values >= 4.21, p-values <= 0.044). Our results support a role for ghrelin in reward processing that extends beyond food-related rewards. Reduced sensitivity to negative outcomes and increased processing of prediction errors may be beneficial for food foraging when hungry but could also relate to increased risk taking and impulsivity in the broader context of addictive behaviors.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Yngve, Adam,1993-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)adayn65
(author)
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Hamilton, Paul J.,1970-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)pauha77
(author)
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Asratian, Anna,1991-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)annas44
(author)
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Gauffin, EmelieLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)emega39
(author)
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Löfberg, Andreas,1987-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)andlo97
(author)
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Gustavson, SarahLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)n/a
(author)
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Persson, Emil,1982-Linköpings universitet,Nationalekonomi,Filosofiska fakulteten,Jedilab(Swepub:liu)emipe01
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Johansson Capusan, Andrea,MD PhD,1970-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)andjo07
(author)
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Leggio, LorenzoNatl Inst Drug Abuse Intramural Res Program, MD 21224 USA; Natl Inst Alcohol Abuse & Alcoholism, MD 21224 USA
(author)
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Perini, Irene,1983-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)irepe41
(author)
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Tinghög, Gustav,1979-Linköpings universitet,Nationalekonomi,Filosofiska fakulteten,Jedilab(Swepub:liu)gusti22
(author)
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Heilig, Markus,1959-Linköpings universitet,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)marhe41
(author)
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Böhme, RebeccaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)rebbo11
(author)
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Linköpings universitetCentrum för social och affektiv neurovetenskap
(creator_code:org_t)
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In:Neuropsychopharmacology: Springer Science+Business Media B.V.49, s. 1042-10490893-133X1740-634X
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