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  • Pincikova, TereziaUppsala universitet,Lung- allergi- och sömnforskning,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Pediat, Stockholm, Sweden; Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden; Karolinska Univ Hosp Huddinge, Dept Resp Med & Allergy, K85, S-14186 Stockholm, Sweden (författare)

MAIT cell counts are associated with the risk of hospitalization in COPD

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-05-18
  • BioMed Central (BMC),2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-475569
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-475569URI
  • https://doi.org/10.1186/s12931-022-02045-2DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149639007URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundChronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with chronic inflammation in the airways. Mucosal-associated invariant T (MAIT) cells are unconventional, innate-like T cells highly abundant in mucosal tissues including the lung. We hypothesized that the characteristics of MAIT cells in circulation may be prospectively associated with COPD morbidity.MethodsCOPD subjects (n = 61) from the Tools for Identifying Exacerbations (TIE) study were recruited when in stable condition. At study entry, forced expiratory volume in 1 s (FEV1) was measured and peripheral blood mononuclear cells were cryopreserved for later analysis by flow cytometry. Patients were followed for 3 years to record clinically meaningful outcomes.ResultsPatients who required hospitalization at one or more occasions during the 3-year follow-up (n = 21) had lower MAIT cell counts in peripheral blood at study inclusion, compared with patients who did not get hospitalized (p = 0.036). In contrast, hospitalized and never hospitalized patients did not differ in CD8 or CD4 T cell counts (p = 0.482 and p = 0.221, respectively). Moreover, MAIT cells in hospitalized subjects showed a more activated phenotype with higher CD38 expression (p = 0.014), and there was a trend towards higher LAG-3 expression (p = 0.052). Conventional CD4 and CD8 T cells were similar between the groups. Next we performed multi-variable logistic regression analysis with hospitalizations as dependent variable, and FEV1, GOLD 2017 group, and quantity or activation of MAIT and conventional T cells as independent variables. MAIT cell count, CD38 expression on MAIT cells, and LAG-3 expression on both MAIT and CD8 T cells were all independently associated with the risk of hospitalization.ConclusionsThese findings suggest that MAIT cells might reflect a novel, FEV1-independent immunological dimension in the complexity of COPD. The potential implication of MAIT cells in COPD pathogenesis and MAIT cells’ prognostic potential deserve further investigation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Parrot, TiphaineKarolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. (författare)
  • Hjelte, LenaKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Pediat, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Stockholm CF Ctr, Stockholm, Sweden. (författare)
  • Högman, MarieannUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)marihogm (författare)
  • Lisspers, Karin,Docent,1954-Uppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)kalis120 (författare)
  • Ställberg, Björn,DocentUppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)bjsta623 (författare)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (författare)
  • Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi(Swepub:uu)anmal535 (författare)
  • Sandberg, Johan K.Karolinska Institutet,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. (författare)
  • Uppsala universitetLung- allergi- och sömnforskning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Respiratory Research: BioMed Central (BMC)23:11465-99211465-993X

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