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  • Legge, AlexandraDalhousie University (author)

Construction of a frailty index as a novel health measure in systemic lupus erythematosus

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-04-15
  • The Journal of Rheumatology,2020
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:35ea5579-3bd0-4a93-a60e-1d8f675a42f0
  • https://lup.lub.lu.se/record/35ea5579-3bd0-4a93-a60e-1d8f675a42f0URI
  • https://doi.org/10.3899/jrheum.181338DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143338344URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective. To construct a Frailty Index (FI) as a measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. Methods. The SLICC inception cohort consists of recently diagnosed patients with SLE followed annually with clinical and laboratory assessments. For this analysis, the baseline visit was defined as the first study visit at which sufficient information was available for construction of an FI. Following a standard procedure, variables from the SLICC database were evaluated as potential health deficits. Selected health deficits were then used to generate a SLICC-FI. The prevalence of frailty in the baseline dataset was evaluated using established cutpoints for FI values. Results. The 1683 patients with SLE (92.1% of the overall cohort) eligible for inclusion in the baseline dataset were mostly female (89%) with mean (SD) age 35.7 (13.4) years and mean (SD) disease duration 18.8 (15.7) months at baseline. Of 222 variables, 48 met criteria for inclusion in the SLICC-FI. Mean (SD) SLICC-FI was 0.17 (0.08) with a range from 0 to 0.51. At baseline, 27.1% (95% CI 25.0-29.2) of patients were classified as frail, based on SLICC-FI values > 0.21. Conclusion. The SLICC inception cohort permits feasible construction of an FI for use in patients with SLE. Even in a relatively young cohort of patients with SLE, frailty was common. The SLICC-FI may be a useful tool for identifying patients with SLE who are most vulnerable to adverse outcomes, but validation of this index is required prior to its use.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kirkland, SusanDalhousie University (author)
  • Rockwood, KennethDalhousie University (author)
  • Andreou, PantelisDalhousie University (author)
  • Bae, Sang CheolHanyang University (author)
  • Gordon, CarolineUniversity of Birmingham (author)
  • Romero-Diaz, JuanitaInstituto Nacional de Ciencias Médicas y Nutrición (author)
  • Sanchez-Guerrero, JorgeInstituto Nacional de Ciencias Médicas y Nutrición (author)
  • Wallace, Daniel J.Jonsson Comprehensive Cancer Center (author)
  • Bernatsky, SashaMcGill University (author)
  • Clarke, Ann E. (author)
  • Merrill, Joan T.Oklahoma Medical Research Foundation (author)
  • Ginzler, Ellen M.SUNY Downstate Health Sciences University (author)
  • Fortin, PaulLaval University (author)
  • Gladman, Dafna D.University of Toronto (author)
  • Urowitz, Murray B.University of Toronto (author)
  • Bruce, Ian N.Manchester Academic Health Science Centre (author)
  • Isenberg, David A.University College London (author)
  • Rahman, AnisurUniversity College London (author)
  • Alarcon, Graciela S.University of Alabama (author)
  • Petri, MichelleJohns Hopkins University (author)
  • Khamashta, Munther A. (author)
  • Dooley, M. A.University of North Carolina (author)
  • Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine (author)
  • Manzi, SusanAllegheny Health Network (author)
  • Zoma, Asad A.Hairmyres Hospital (author)
  • Aranow, CynthiaFeinstein Institute for Medical Research (author)
  • MacKay, MegganFeinstein Institute for Medical Research (author)
  • Ruiz-Irastorza, GuillermoUniversity of the Basque Country (author)
  • Lim, S. SamEmory University (author)
  • Inanc, Murat (author)
  • Van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute (author)
  • Jonsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)reum-ajo (author)
  • Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni (author)
  • Ramos-Casals, ManuelHospital Clínic of Barcelona (author)
  • Kamen, Diane L.Medical University of South Carolina (author)
  • Kalunian, Kenneth C.University of California, San Diego (author)
  • Jacobsen, SorenCopenhagen University Hospital (author)
  • Peschken, Christine A.University of Manitoba (author)
  • Askanase, AncaIndian Institute of Technology (author)
  • Hanly, John G.Dalhousie University (author)
  • Dalhousie UniversityHanyang University (creator_code:org_t)

Related titles

  • In:Journal of Rheumatology: The Journal of Rheumatology47:1, s. 72-810315-162X1499-2752

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