Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis

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Marwa, KarolCatholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania. (författare)

Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa : A systematic review and meta-analysis

Artikel/kapitelEngelska2022

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2022-03-10
Public Library of Science (PLoS),2022
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LIBRIS-ID:oai:DiVA.org:uu-481362
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481362URI
https://doi.org/10.1371/journal.pone.0264339DOI

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BackgroundSub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the global burden of malaria. In the effort to facilitate early detection of resistance for artemisinin derivatives and partner drugs, WHO recommends monitoring of ACT's efficacy in the malaria endemic countries. The present systematic meta-analysis study summarises the evidence of therapeutic efficacy of the commonly used artemisinin-based combinations for the treatment of uncomplicated P. falciparum malaria in Sub-Saharan Africa after more than a decade since the introduction of the drugs.MethodsFifty two studies carried out from 2010 to 2020 on the efficacy of artemether-lumefantrine or dihydro-artemisinin piperaquine or artesunate amodiaquine in patients with uncomplicated P. falciparum malaria in Sub-Saharan Africa were searched for using the Google Scholar, Cochrane Central Register of controlled trials (CENTRAL), PubMed, Medline, LILACS, and EMBASE online data bases. Data was extracted by two independent reviewers. Random analysis effect was performed in STATA 13. Heterogeneity was established using I-2 statistics.ResultsBased on per protocol analysis, unadjusted cure rates in malaria infected patients treated with artemether-lumefantrine (ALU), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DHP) were 89%, 94% and 91% respectively. However, the cure rates after PCR correction were 98% for ALU, 99% for ASAQ and 99% for DHP.ConclusionThe present meta-analysis reports the overall high malaria treatment success for artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine above the WHO threshold value in Sub-Saharan Africa.

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Kapesa, AnthonyCatholic Univ Hlth & Allied Sci, Dept Community Med, Mwanza, Tanzania. (författare)
Baraka, VitoNatl Inst Med Res, Tanga Ctr, Tanga, Tanzania. (författare)
Konje, EvelyneCatholic Univ Hlth & Allied Sci, Dept Epidemiol, Mwanza, Tanzania. (författare)
Kidenya, BensonCatholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania. (författare)
Mukonzo, JacksonMakerere Univ, Dept Pharmacol & Therapeut, Kampala, Uganda. (författare)
Kamugisha, ErasmusCatholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania. (författare)
Swedberg, GöteUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)goteswed (författare)
Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.Catholic Univ Hlth & Allied Sci, Dept Community Med, Mwanza, Tanzania. (creator_code:org_t)

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Ingår i:PLOS ONE: Public Library of Science (PLoS)17:31932-6203

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Av författaren/redakt...: Marwa, Karol; Kapesa, Anthony; Baraka, Vito; Konje, Evelyne; Kidenya, Benson; Mukonzo, Jackson; visa fler...; Kamugisha, Erasm ...; Swedberg, Göte; visa färre...

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