Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis

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Fältnamn	Indikatorer	Metadata
000		04215naa a2200397 4500
001		oai:DiVA.org:uu-481362
003		SwePub
008		220809s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4813622 URI
024	7	a https://doi.org/10.1371/journal.pone.02643392 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Marwa, Karolu Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.4 aut
245	1 0	a Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa :b A systematic review and meta-analysis
264		c 2022-03-10
264	1	b Public Library of Science (PLoS),c 2022
338		a electronic2 rdacarrier
520		a BackgroundSub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the global burden of malaria. In the effort to facilitate early detection of resistance for artemisinin derivatives and partner drugs, WHO recommends monitoring of ACT's efficacy in the malaria endemic countries. The present systematic meta-analysis study summarises the evidence of therapeutic efficacy of the commonly used artemisinin-based combinations for the treatment of uncomplicated P. falciparum malaria in Sub-Saharan Africa after more than a decade since the introduction of the drugs.MethodsFifty two studies carried out from 2010 to 2020 on the efficacy of artemether-lumefantrine or dihydro-artemisinin piperaquine or artesunate amodiaquine in patients with uncomplicated P. falciparum malaria in Sub-Saharan Africa were searched for using the Google Scholar, Cochrane Central Register of controlled trials (CENTRAL), PubMed, Medline, LILACS, and EMBASE online data bases. Data was extracted by two independent reviewers. Random analysis effect was performed in STATA 13. Heterogeneity was established using I-2 statistics.ResultsBased on per protocol analysis, unadjusted cure rates in malaria infected patients treated with artemether-lumefantrine (ALU), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DHP) were 89%, 94% and 91% respectively. However, the cure rates after PCR correction were 98% for ALU, 99% for ASAQ and 99% for DHP.ConclusionThe present meta-analysis reports the overall high malaria treatment success for artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine above the WHO threshold value in Sub-Saharan Africa.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
700	1	a Kapesa, Anthonyu Catholic Univ Hlth & Allied Sci, Dept Community Med, Mwanza, Tanzania.4 aut
700	1	a Baraka, Vitou Natl Inst Med Res, Tanga Ctr, Tanga, Tanzania.4 aut
700	1	a Konje, Evelyneu Catholic Univ Hlth & Allied Sci, Dept Epidemiol, Mwanza, Tanzania.4 aut
700	1	a Kidenya, Bensonu Catholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania.4 aut
700	1	a Mukonzo, Jacksonu Makerere Univ, Dept Pharmacol & Therapeut, Kampala, Uganda.4 aut
700	1	a Kamugisha, Erasmusu Catholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania.4 aut
700	1	a Swedberg, Göteu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)goteswed
710	2	a Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.b Catholic Univ Hlth & Allied Sci, Dept Community Med, Mwanza, Tanzania.4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 17:3q 17:3x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0264339y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1686397/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481362
856	4 8	u https://doi.org/10.1371/journal.pone.0264339

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Av författaren/redakt...: Marwa, Karol; Kapesa, Anthony; Baraka, Vito; Konje, Evelyne; Kidenya, Benson; Mukonzo, Jackson; visa fler...; Kamugisha, Erasm ...; Swedberg, Göte; visa färre...

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