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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004262naa a2200493 4500
001oai:DiVA.org:uu-237311
003SwePub
008141201s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2373112 URI
0247 a https://doi.org/10.1016/j.jacc.2014.05.0692 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Danad, Ibrahim4 aut
2451 0a Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease Cutoff Values and Diagnostic Accuracy of Quantitative [O-15]H2O PET Imaging
264 1b Elsevier BV,c 2014
338 a print2 rdacarrier
520 a BACKGROUND Recent studies have demonstrated improved diagnostic accuracy for detecting coronary artery disease (CAD) when myocardial blood flow (MBF) is quantified in absolute terms, but there are no uniformly accepted cutoff values for hemodynamically significant CAD. OBJECTIVES The goal of this study was to determine cutoff values for absolute MBF and to evaluate the diagnostic accuracy of quantitative [O-15]H2O positron emission tomography (PET). METHODS A total of 330 patients underwent both quantitative [O-15]H2O PET imaging and invasive coronary angiography in conjunction with fractional flow reserve measurements. A stenosis >90% and/or fractional flow reserve <= 0.80 was considered obstructive; a stenosis <30% and/or fractional flow reserve >0.80 was nonobstructive. RESULTS Hemodynamically significant CAD was diagnosed in 116 (41%) of 281 patients who fulfilled study criteria for CAD. Resting perfusion was 1.00 +/- 0.25 and 0.92 +/- 0.23 ml/min/g in regions supplied by nonstenotic and significantly stenosed vessels, respectively (p < 0.001). During stress, perfusion increased to 3.26 +/- 1.04 ml/min/g and 1.73 +/- 0.67 ml/min/g, respectively (p < 0.001). The optimal cutoff values were 2.3 and 2.5 for hyperemic MBF and myocardial flow reserve, respectively. For MBF, these cutoff values showed a sensitivity, specificity, and accuracy for detecting significant CAD of 89%, 84%, and 86%, respectively, at a per-patient level and 87%, 85%, and 85% at a per-vessel level. The corresponding myocardial flow reserve values were 86%, 72%, and 78% (per patient) and 80%, 82%, and 81% (per vessel). Age and sex significantly affected diagnostic accuracy of quantitative PET. CONCLUSIONS Quantitative MBF measurements with the use of [O-15]H2O PET provided high diagnostic performance, but both sex and age should be taken into account.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a myocardial blood flow
653 a myocardial flow reserve
653 a receiver-operator characteristic curve
653 a sensitivity
653 a specificity
7001 a Uusitalo, Valtteri4 aut
7001 a Kero, Tanjau Uppsala universitet,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)tanke311
7001 a Saraste, Antti4 aut
7001 a Raijmakers, Pieter G.u Uppsala universitet,Enheten för nuklearmedicin och PET4 aut
7001 a Lammertsma, Adriaan A.u Uppsala universitet,Enheten för nuklearmedicin och PET4 aut
7001 a Heymans, Martijn W.4 aut
7001 a Kajander, Sami A.4 aut
7001 a Pietilae, Mikko4 aut
7001 a James, Stefan K.u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Sörensen, Jensu Uppsala universitet,Klinisk fysiologi,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)jenssore
7001 a Knaapen, Paul4 aut
7001 a Knuuti, Juhani4 aut
7102 a Uppsala universitetb Enheten för nuklearmedicin och PET4 org
7730 t Journal of the American College of Cardiologyd : Elsevier BVg 64:14, s. 1464-1475q 64:14<1464-1475x 0735-1097x 1558-3597
8564 u https://doi.org/10.1016/j.jacc.2014.05.069
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237311
8564 8u https://doi.org/10.1016/j.jacc.2014.05.069

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