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Effect of postopera...
Effect of postoperative insulin-like growth factor I supplementation on protein metabolism in humans
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- Leinsköld, Ted (author)
- Linköpings universitet,Avdelningen för kirurgi,Hälsouniversitetet
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- Permert, J. (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för kirurgi,Hälsouniversitetet
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- Olaison, Gunnar (author)
- Linköpings universitet,Avdelningen för kirurgi,Hälsouniversitetet
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- Larsson, J. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2005-12-14
- 1995
- English.
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In: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 82:7, s. 921-925
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Insulin-like growth factor I (IGF-I) has been shown experimentally to exert a nitrogen-sparing effect in both animals and humans. Its effects on protein metabolism during the first 5 days after radical large bowel resection were investigated. Nineteen patients were randomly allocated to receive either human recombinant IGF-I (2 × 80 μ/kg body weight subcutaneously, n = 10) or placebo (n = 9) starting on the morning of the first day after operation. All patients received parenteral nutrition (glucose 3 g and nitrogen 0.1 g/kg/day). The mean(s.e.m.) urinary nitrogen: creatinine ratio was significantly reduced in patients who received IGF-I compared with those given placebo (275.0(17.1) compared with 386.3(23.6), P<0.01). The mean urinary 3-methylhistidine: creatinine ratio and nitrogen balance were lower in the IGF-I group, but not significantly so. Plasma IGF-I concentrations were four times higher in the treated group compared with those in the placebo group. Insulin-like growth factor binding protein 3 (IGFBP-3) increased significantly after the start of IGF-I treatment, compared with mean postoperative levels. The mean blood glucose concentration was significantly lower in the IGF-I group than the placebo group (P < 0.05) but no patient had a hypoglycaemic attack. The authors conclude that IGF-I does not significantly influence the nitrogen balance, but that results indicate a possible nitrogen-sparing effect in patients after major abdominal operations. IGF-I therapy is safe, and may be of value in catabolic patients after serious injury and major operations.
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- art (subject category)
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