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White matter hyperi...
White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study
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- Schirmer, M. D. (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Massachusetts General Hospital,Massachusetts Institute of Technology
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- Dalca, A. V. (author)
- Massachusetts Institute of Technology,Massachusetts General Hospital,University of Cincinnati College of Medicine
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- Sridharan, R. (author)
- Massachusetts Institute of Technology,Massachusetts General Hospital
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- Giese, A. K. (author)
- Massachusetts General Hospital,Broad Institute
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- Donahue, K. L. (author)
- Massachusetts General Hospital
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- Nardin, M. J. (author)
- Massachusetts General Hospital
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- Mocking, S. J. T. (author)
- Massachusetts General Hospital
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- McIntosh, E. C. (author)
- Massachusetts General Hospital
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- Frid, Petrea (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wasselius, Johan (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital,Veterans Health Administration
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Cole, J. W. (author)
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- Holmegaard, Lukas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska Academy
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- Jern, Christina, 1962 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Jimenez-Conde, J. (author)
- Autonomous University of Barcelona
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- Lemmens, R. (author)
- University Hospitals Leuven,Catholic University of Leuven,University of Miami
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- Lindgren, Arne G. (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Meschia, J. F. (author)
- Mayo Clinic Florida
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- Roquer, J. (author)
- Autonomous University of Barcelona
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- Rundek, T. (author)
- University of Miami
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Sacco, R. L. (author)
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- Schmidt, R. (author)
- Medical University of Graz
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- Sharma, P. (author)
- Royal Holloway University of London
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- Slowik, A. (author)
- Jagiellonian University
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Thijs, V. (author)
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- Woo, D. (author)
- University of Cincinnati College of Medicine
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Vagal, A. (author)
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- Xu, H. C. (author)
- University of Maryland School of Medicine
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- Kittner, S. J. (author)
- Veterans Health Administration
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- McArdle, P. F. (author)
- University of Maryland School of Medicine
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- Mitchell, B. D. (author)
- University of Maryland School of Medicine
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- Rosand, J. (author)
- Massachusetts General Hospital
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- Worrall, B. B. (author)
- University of Virginia
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- Wu, O. (author)
- Massachusetts General Hospital
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- Golland, P. (author)
- Massachusetts Institute of Technology
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Rost, N. S. (author)
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(creator_code:org_t)
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- Elsevier BV, 2019
- 2019
- English.
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In: Neuroimage-Clinical. - : Elsevier BV. - 2213-1582. ; 23
- Related links:
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https://doi.org/10.1...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinical MRI often rely on time intensive manual delineation of the disease on T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses such as genetic discovery. In this work, we present a fully automated pipeline for quantification of WMH in clinical large-scale studies of AIS. The pipeline incorporates automated brain extraction, intensity normalization and WMH segmentation using spatial priors. We first propose a brain extraction algorithm based on a fully convolutional deep learning architecture, specifically designed for clinical FLAIR images. We demonstrate that our method for brain extraction outperforms two commonly used and publicly available methods on clinical quality images in a set of 144 subject scans across 12 acquisition centers, based on dice coefficient (median 0.95; inter-quartile range 0.94-0.95; p < 0.01) and Pearson correlation of total brain volume (r = 0.90). Subsequently, we apply it to the large-scale clinical multi-site MRI-GENIE study (N = 2783) and identify a decrease in total brain volume of -2.4 cc/year. Additionally, we show that the resulting total brain volumes can successfully be used for quality control of image preprocessing. Finally, we obtain WMH volumes by building on an existing automatic WMH segmentation algorithm that delineates and distinguishes between different cerebrovascular pathologies. The learning method mimics expert knowledge of the spatial distribution of the WMH burden using a convolutional auto-encoder. This enables successful computation of WMH volumes of 2533 clinical AIS patients. We utilize these results to demonstrate the increase of WMH burden with age (0.950 cc/year) and show that single site estimates can be biased by the number of subjects recruited.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- determinants
- performance
- burden
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Schirmer, M. D.
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Dalca, A. V.
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Sridharan, R.
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Giese, A. K.
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Donahue, K. L.
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Nardin, M. J.
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show more...
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Mocking, S. J. T ...
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McIntosh, E. C.
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Frid, Petrea
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Wasselius, Johan
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Cole, J. W.
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Holmegaard, Luka ...
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Jern, Christina, ...
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Jimenez-Conde, J ...
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Lemmens, R.
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Lindgren, Arne G ...
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Meschia, J. F.
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Roquer, J.
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Rundek, T.
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Sacco, R. L.
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Schmidt, R.
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Sharma, P.
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Slowik, A.
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Thijs, V.
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Woo, D.
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Vagal, A.
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Xu, H. C.
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Kittner, S. J.
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McArdle, P. F.
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Mitchell, B. D.
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Rosand, J.
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Worrall, B. B.
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Wu, O.
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Golland, P.
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Rost, N. S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neuroimage-Clini ...
- By the university
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University of Gothenburg
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Lund University