Sökning: WFRF:(Levin Max 1969) > A single early post...
Fältnamn | Indikatorer | Metadata |
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000 | 05035naa a2200517 4500 | |
001 | oai:research.chalmers.se:90ceaded-bf70-4070-bbfb-82f4efde309c | |
003 | SwePub | |
008 | 171008s2010 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/107378 | |
009 | oai:DiVA.org:uu-130475 | |
024 | 7 | a https://research.chalmers.se/publication/1073782 URI |
024 | 7 | a https://doi.org/10.1016/j.jsbmb.2009.10.0062 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/1073782 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1304752 URI |
040 | a (SwePub)cthd (SwePub)gud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Alexanderson, Camilla,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xaleca |
245 | 1 0 | a A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats. |
264 | 1 | b Elsevier BV,c 2010 |
520 | a Events during early life can affect reproductive and metabolic functions in adulthood. We evaluated the programming effects of a single early postnatal estradiol injection (within 3h after birth) in female rats. We assessed ovarian and parametrial adipose tissue morphology, evaluated gene expression related to follicular development and adipose tissue metabolism, and developed a non-invasive volumetric estimation of parametrial adipose tissue by magnetic resonance imaging. Estradiol reduced ovarian weight, increased antral follicle size and number of atretic antral follicles, and decreased theca interna thickness in atretic antral follicles. Adult estradiol-injected rats also had malformed vaginal openings and lacked corpora lutea, confirming anovulation. Estradiol markedly reduced parametrial adipose tissue mass. Adipocyte size was unchanged, suggesting reduced adipocyte number. Parametrial adipose tissue lipoprotein lipase activity was increased. In ovaries, estradiol increased mRNA expression of adiponectin, complement component 3, estrogen receptor alpha, and glucose transporter 3 and 4; in parametrial adipose tissue, expression of complement component 3 was increased, expression of estrogen receptor alpha was decreased, and expression of leptin, lipoprotein lipase, and hormone-sensitive lipase was unaffected. These findings suggest that early postnatal estradiol exposure of female rats result in long-lasting effects on the ovary and parametrial adipose tissue at adult age. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a Parametrial adipose tissue | |
653 | a Ovary | |
653 | a Estradiol | |
653 | a Programming | |
653 | a Estradiol; Programming; Ovary; Parametrial adipose tissue | |
653 | a MEDICINE | |
700 | 1 | a Stener-Victorin, Elisabet,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xsteel |
700 | 1 | a Kullberg, Joelu Uppsala universitet,Enheten för radiologi4 aut0 (Swepub:uu)jokul377 |
700 | 1 | a Nilsson, Staffan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics4 aut0 (Swepub:gu)xnista |
700 | 1 | a Levin, Max,d 1969u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xlevma |
700 | 1 | a Cajander, Stefan,d 1948u Uppsala universitet,Institutionen för genetik och patologi4 aut |
700 | 1 | a Lönn, Lars,d 1956u Rigshospitalet4 aut0 (Swepub:gu)xlonla |
700 | 1 | a Lönn, Malin,d 1959u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xlonnm |
700 | 1 | a Holmäng, Agneta,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xholag |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
773 | 0 | t The Journal of steroid biochemistry and molecular biologyd : Elsevier BVg 122:1-3, s. 82-90q 122:1-3<82-90x 1879-1220x 0960-0760 |
856 | 4 | u http://dx.doi.org/10.1016/j.jsbmb.2009.10.006y FULLTEXT |
856 | 4 8 | u https://research.chalmers.se/publication/107378 |
856 | 4 8 | u https://doi.org/10.1016/j.jsbmb.2009.10.006 |
856 | 4 8 | u https://gup.ub.gu.se/publication/107378 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130475 |
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